Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B

Background & Aims Aim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms (SNPs) of the IL‐28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HBsAg persistence. Further, a potential effect on the development...

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Bibliographic Details
Published in:Liver international 2015-03, Vol.35 (3), p.846-853
Main Authors: Karataylı, Senem C., Bozdayı, Mithat, Karataylı, Ersin, Öztürk, Tuğba, Husseini, Abbas A., Albayrak, Rabia, Özkan, Muhip, Kalaylıoğlu, Zeynep, Yalçın, Kendal, Çınar, Kubilay, İdilman, Ramazan, Yurdaydın, Cihan
Format: Article
Language:English
Subjects:
Adult
Carrier State
Cohort Studies
DNA, Viral - blood
Female
Genotype
Hepatitis B e Antigens - blood
hepatitis B infection
Hepatitis B Surface Antigens - blood
Hepatitis B virus
Hepatitis B, Chronic - genetics
Hepatitis D, Chronic - genetics
hepatitis delta infection
Humans
interferon lambda 3
Interferons
interleukin 28 B
Interleukins - genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
single nucleotide polymorphisms
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Summary:Background & Aims Aim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms (SNPs) of the IL‐28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HBsAg persistence. Further, a potential effect on the development of HBeAg‐negative CHB vs. inactive HBsAg carrier state was assessed in a genotype D HBV cohort. A cohort of chronic HDV patients was also used to see if they behave differently compared to chronic HBV patients. Methods This study was conducted in three main patient cohorts: Group 1 consisted of 482 patients with HBsAg persistence. Of them 143 were inactive carriers, 94 had HBeAg‐positive chronic hepatitis B (CHB) and 245 had anti‐HBe‐positive CHB. Group 2 represents spontaneously recovered HBV patients; they were anti‐HBs and anti‐HBc positive. Group 3 consisted of 176 chronic hepatitis delta (CHD) patients with antidelta and HDV‐RNA positivity. DNA sequencing was performed for genotyping. Results When patients with HBsAg persistence were compared with spontaneously recovered patients, a significant difference was observed for rs8105790 (P 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.12595