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Reduction of cortical excitability and increase of thalamic activity in a low-frequency rTMS treatment for chronic tinnitus
Low-frequency repetitive transcranial magnetic stimulation (rTMS) has received increasing attention for the treatment of tinnitus, but its therapeutic mechanisms are unclear. We performed low-frequency rTMS treatment for a patient with chronic tinnitus and examined changes of cortical excitability a...
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| Published in: | Neurocase 2015-05, Vol.21 (3), p.339-344 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c499t-cdbbe3dea90659b0d9636034a48b2224abb82167ce53a876d636e1317b8666fb3 |
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| cites | cdi_FETCH-LOGICAL-c499t-cdbbe3dea90659b0d9636034a48b2224abb82167ce53a876d636e1317b8666fb3 |
| container_end_page | 344 |
| container_issue | 3 |
| container_start_page | 339 |
| container_title | Neurocase |
| container_volume | 21 |
| creator | Takahashi, Shun Ukai, Satoshi Tsuji, Tomikimi Ueyama, Takashi Kono, Masamitsu Yamanaka, Noboru Shinosaki, Kazuhiro |
| description | Low-frequency repetitive transcranial magnetic stimulation (rTMS) has received increasing attention for the treatment of tinnitus, but its therapeutic mechanisms are unclear. We performed low-frequency rTMS treatment for a patient with chronic tinnitus and examined changes of cortical excitability and cerebral blood flow using paired-pulse TMS and single-photon emission computed tomography. After the rTMS treatment, tinnitus loudness was decreased, cortical excitability was reduced, and blood flow in the thalamus was increased. Our results suggest that low-frequency rTMS treatment reduces tinnitus loudness by an inhibitory effect on the cortical excitability and a remote activation effect on the thalamus through the corticothalamic networks. |
| doi_str_mv | 10.1080/13554794.2014.893000 |
| format | article |
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| ispartof | Neurocase, 2015-05, Vol.21 (3), p.339-344 |
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| language | eng |
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| source | Taylor & Francis |
| subjects | cerebral blood flow Cerebral Cortex - physiopathology Cerebrovascular Circulation - physiology Chronic Disease cortical excitability Female Humans Middle Aged paired-pulse transcranial magnetic stimulation Positron-Emission Tomography repetitive transcranial magnetic stimulation thalamus Thalamus - physiopathology tinnitus Tinnitus - therapy Tomography, Emission-Computed, Single-Photon Transcranial Magnetic Stimulation - methods |
| title | Reduction of cortical excitability and increase of thalamic activity in a low-frequency rTMS treatment for chronic tinnitus |
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