Semi-quantitative HPV viral load in patients with ASC-US cytology: viral load correlates strongly with the presence of CIN but only weakly with its severity

Objectives This study was performed to evaluate the prognostic significance of human papillomavirus (HPV) viral load, expressed in relative light units (RLUs), in patients with atypical squamous cells of undetermined significance (ASC‐US) cytology. Methods A total of 349 ASC‐US cases with HPV infect...

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Bibliographic Details
Published in:Cytopathology (Oxford) 2015-02, Vol.26 (1), p.19-25
Main Authors: Lee, S. J., Kim, W. Y., Shim, S.-H., Cho, S.-H., Oh, I. K., Hwang, T. S., Kim, S.-N., Kang, S.-B.
Format: Article
Language:English
Subjects:
Adult
ASC-US
Atypical Squamous Cells of the Cervix
atypical squamous cells of undetermined significance
atypical squamous cells of undetermined significance, ASC‐US
cervical intraepithelial neoplasia
Cervical Intraepithelial Neoplasia - diagnosis
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - virology
cervical intraepithelial neoplasia, CIN
CIN
Colposcopy
Cytodiagnosis
Female
HPV
HPV, viral load
human papillomavirus
Humans
Middle Aged
Neoplasm Staging
Papillomaviridae - pathogenicity
Papillomavirus Infections - diagnosis
Papillomavirus Infections - pathology
Papillomavirus Infections - virology
Pregnancy
Prognosis
Viral Load
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Summary:Objectives This study was performed to evaluate the prognostic significance of human papillomavirus (HPV) viral load, expressed in relative light units (RLUs), in patients with atypical squamous cells of undetermined significance (ASC‐US) cytology. Methods A total of 349 ASC‐US cases with HPV infection, detected using Hybrid Capture 2, were diagnosed histologically. A colposcopically directed punch biopsy was performed on acetowhite areas. Endocervical curettage biopsy and random cervical punch biopsy in four quadrants were performed in unsatisfactory colposcopy cases. In negative colposcopy cases, random cervical punch biopsy in four quadrants was performed. Results Case with no cervical intraepithelial neoplasia (CIN), CIN1 and CIN2+ (CIN2/CIN3) accounted for 162, 135 and 52 cases, respectively. The mean age showed no difference among the three groups (P = 0.510). There was a significant correlation between RLU values and the presence of CIN (P 
ISSN:0956-5507
1365-2303
DOI:10.1111/cyt.12146