Numerical Model of Dog Mast Cell Tumor Treated by Electrochemotherapy

Electrochemotherapy is a combination of high electric field and anticancer drugs. The treatment basis is electroporation or electropermeabilization of the cell membrane. Electroporation is a threshold phenomenon and, for efficient treatment, an adequate local distribution of electric field within th...

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Bibliographic Details
Published in:Artificial organs 2015-02, Vol.39 (2), p.192-197
Main Authors: Suzuki, Daniela O.H., Anselmo, Jânio, de Oliveira, Krishna D., Freytag, Jennifer O., Rangel, Marcelo M.M., Marques, Jefferson L.B., Ramos, Airton
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Computer Simulation
Dog Diseases - pathology
Dog Diseases - therapy
Dogs
Electric fields
Electrochemotherapy
Electrochemotherapy - methods
Mast cell tumor
Mast Cells - pathology
Mastocytosis, Cutaneous - pathology
Mastocytosis, Cutaneous - therapy
Mastocytosis, Cutaneous - veterinary
Medical treatment
Models, Biological
Numerical simulation
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Summary:Electrochemotherapy is a combination of high electric field and anticancer drugs. The treatment basis is electroporation or electropermeabilization of the cell membrane. Electroporation is a threshold phenomenon and, for efficient treatment, an adequate local distribution of electric field within the treated tissue is important. When this local electric field is not enough, there is a regrown tumor cell; however, if it is stronger than necessary, permanent damage to the tissue occurs. In the treatment of dogs, electrochemotherapy is not yet an established treatment for mast cell tumor in veterinary medicine, although there are studies showing evidence of its effectiveness. In this study, we examined electrochemotherapy of dog mast cell tumor with numerical simulation of local electric field distribution. The experimental result was used to validate the numerical models. The effect of tumor position and tissue thickness (tumor in different parts of dog body) was investigated using plate electrodes. Our results demonstrated that the electrochemotherapy is efficient and flexible, and even when the tumor extends into the subcutis, the treatment with plate electrode eliminated the tumor cells. This result suggests that electrochemotherapy is a suitable method to treat mast cell tumors in dog.
ISSN:0160-564X
1525-1594
DOI:10.1111/aor.12333