Effective treatment of invasive Aspergillus fumigatus infection using combinations of topical and systemic antifungals in a severely burned patient

The authors describe an invasive Aspergillus fumigatus deep-burn wound infection in a severely burned patient that was successfully treated with a combination of topical terbinafine and systemic voriconazole antifungal therapy. To our knowledge, this is the first case report describing the effective...

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Bibliographic Details
Published in:Journal of burn care & research 2015-03, Vol.36 (2), p.e85-e89
Main Authors: Fournier, Anne, Pantet, Olivier, Guerid, Samia, Eggimann, Philippe, Pagani, Jean-Luc, Revelly, Jean-Pierre, Hauser, Philippe M, Marchetti, Oscar, Fontanella, Sara, Letovanec, Igor, Ravat, François, Berger, Mette M, Pannatier, André, Voirol, Pierre, Que, Yok-Ai
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Antifungal Agents - administration & dosage
Aspergillosis - drug therapy
Aspergillosis - microbiology
Aspergillus fumigatus - isolation & purification
Blast Injuries - complications
Blast Injuries - drug therapy
Burns - complications
Burns - drug therapy
Fatal Outcome
Humans
Male
Sepsis - drug therapy
Sepsis - microbiology
Wound Infection - drug therapy
Wound Infection - microbiology
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Summary:The authors describe an invasive Aspergillus fumigatus deep-burn wound infection in a severely burned patient that was successfully treated with a combination of topical terbinafine and systemic voriconazole antifungal therapy. To our knowledge, this is the first case report describing the effective control of an invasive deep-burn wound infection using this combination.
ISSN:1559-047X
1559-0488
DOI:10.1097/BCR.0000000000000143