Antibody transport and internalization into tumors

Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumor targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating interna...

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Bibliographic Details
Published in:British journal of cancer 1990, Vol.62, p.1-5
Main Authors: Matzku, S, Moldenhauer, G, Kalthoff, H, Canevari, S, Colnaghi, M, Schuhmacher, J, Bihl, H
Format: Article
Language:English
Online Access:Get full text
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Summary:Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumor targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.
ISSN:0007-0920