Thienyl-Substituted Nucleosides and Their Triphosphates

A series of thienyl-substituted nucleosides and their triphosphates has been prepared and the compounds evaluated as antiviral agents. The compounds investigated were 1-(5′-triphosphate-β-D-arabinofuranosyl)-5-(2″-thienyl)uracil (6), 1-(5′-triphosphate-β-D-arabinofuranosyl)-5-(2″-thienyl)cytosin (13...

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Bibliographic Details
Published in:Antiviral chemistry & chemotherapy 1994-12, Vol.5 (6), p.395-402
Main Authors: Persson, T., Hörnfeldt, A.-B., Gronowitz, S., Johansson, N. G.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
human immunodeficiency virus
Medical sciences
Nucleosides
Pharmacology. Drug treatments
Uracil
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Summary:A series of thienyl-substituted nucleosides and their triphosphates has been prepared and the compounds evaluated as antiviral agents. The compounds investigated were 1-(5′-triphosphate-β-D-arabinofuranosyl)-5-(2″-thienyl)uracil (6), 1-(5′-triphosphate-β-D-arabinofuranosyl)-5-(2″-thienyl)cytosin (13) and 1-(5′-triphosphate-2′, 3′-dideoxynbofuranosyl)-5-(2″-thienyl)uracil (19). The activities of (6), (13) and (19) was shown to be inferior to that of the previously prepared compound 5-(2″-thienyl)-β-2′-deoxyuridine triphosphate (20).
ISSN:2040-2066
0956-3202
2040-2066
DOI:10.1177/095632029400500607