Differential impact of stress on hypothalamic–pituitary–adrenal axis: Gene expression changes in Lewis and Fisher rats

• Published in: Psychoneuroendocrinology 2015-03, Vol.53, p.49-59
• Main Authors: Ergang, Peter, Vodička, Martin, Soták, Matúš, Klusoňová, Petra, Behuliak, Michal, Řeháková, Lenka, Zach, Petr, Pácha, Jiří
• Format: Article
• Language: English
• Subjects: 11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics; 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism; 11β-Hydroxysteroid dehydrogenase type 1; Adrenal Cortex - metabolism; Amygdala - metabolism; Animals; Arginine Vasopressin - genetics; Arginine Vasopressin - metabolism; Brain; Brain - metabolism; Corticotropin-Releasing Hormone - genetics; Corticotropin-Releasing Hormone - metabolism; Endocrinology & Metabolism; Fisher rat; Gene Expression Profiling; Hippocampus - metabolism; Hypothalamo-Hypophyseal System - metabolism; Lewis rat; Neuropeptides; Oxytocin - genetics; Oxytocin - metabolism; Paraventricular Hypothalamic Nucleus - metabolism; Pituitary Adenylate Cyclase-Activating Polypeptide - genetics; Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism; Pituitary Gland - metabolism; Pituitary-Adrenal System - metabolism; Prefrontal Cortex - metabolism; Psychiatry; Rats; Rats, Inbred F344; Rats, Inbred Lew; Receptors, Glucocorticoid - genetics; Receptors, Glucocorticoid - metabolism; RNA, Messenger - metabolism; Stress; Stress, Psychological - genetics; Stress, Psychological - metabolism; Urocortins - genetics; Urocortins - metabolism
• ISSN: 0306-4530; 1873-3360
• DOI: 10.1016/j.psyneuen.2014.12.013

Highlights • 11HSD1 and neuropeptide mRNAs were studied in stress hypo- and hyper-responsive rats. • 11HSD1 is not upregulated in PVN, pituitary and adrenal glands. • Stress upregulates 11HSD1 in brain structures associated with regulation of HPA axis and this expression is strain- and stress-dependent. • Expression of CRH, PACAP and urocortin 2 and 3 is strain- and stress-dependent.