One-week versus 2-day ventilator circuit change in neonates with prolonged ventilation: cost-effectiveness and impact on ventilator-associated pneumonia

• Published in: Infection control and hospital epidemiology 2015-03, Vol.36 (3), p.287-293
• Main Authors: Chu, Shih-Ming, Yang, Mei-Chin, Hsiao, Hsiu-Feng, Hsu, Jen-Fu, Lien, Reyin, Chiang, Ming-Chou, Fu, Ren-Huei, Huang, Hsuan-Rong, Hsu, Kuang-Hung, Tsai, Ming-Horng
• Format: Article
• Language: English
• Subjects: Antibiotics; Birth weight; Congenital diseases; Cost analysis; Cost-Benefit Analysis; Female; Gestational age; Heart rate; Humans; Infant, Newborn; Intensive care; Intensive Care, Neonatal - economics; Intensive Care, Neonatal - methods; Intubation; Logistic Models; Male; Mortality; Neonates; Newborn babies; Nosocomial infections; Nursing; Observational studies; Outcome Assessment (Health Care); Patient safety; Pneumonia; Pneumonia, Ventilator-Associated - economics; Pneumonia, Ventilator-Associated - prevention & control; Respiration, Artificial - economics; Respiration, Artificial - methods; Respiratory distress syndrome; Retrospective Studies; Surfactants; Taiwan; Time Factors; Ventilation; Ventilators
• ISSN: 0899-823X; 1559-6834
• DOI: 10.1017/ice.2014.48

To investigate the impact of 1-week ventilator circuit change on ventilator-associated pneumonia and its cost-effectiveness compared with a 2-day change. An observational cohort study. A tertiary level neonatal intensive care unit in a university-affiliated teaching hospital in Taiwan. Patients All neonates in the neonatal intensive care unit receiving invasive intubation for more than 1 week from July 1, 2011, through December 31, 2013. We investigated the impact of 2 ventilator circuit change regimens, either every 2 days or 7 days, on ventilator-associated pneumonia of our cohort. A total of 361 patients were maintained on mechanical ventilators for 13,981 days. The 2 groups did not differ significantly in any demographic characteristics. The rate of ventilator-associated pneumonia was comparable between the 2-day group and the 7-day group (8.2 vs 9.5 per 1,000 ventilator-days, P=.439). The durations of mechanical ventilation and hospital stay, and rates of bloodstream infection and mortality, were also comparable between the 2 groups. Switching from a 2-day to a 7-day change policy would save our neonatal intensive care unit a yearly sum of US $29,350 and 525 working hours. Decreasing the frequency of ventilator circuit changes from every 2 days to once per week is safe and cost-effective in neonates requiring prolonged intubation for more than 1 week.