Indolent lymphoma: follicular lymphoma and the microenvironment-insights from gene expression profiling

As shown with gene expression profiling (GEP), the development and progression of follicular lymphoma (FL) involves complex interactions between neoplastic B cells and the surrounding microenvironment. GEP further reveals that the tumor microenvironment may predict survival in patients with FL and i...

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Bibliographic Details
Published in:Hematology 2014-12, Vol.2014 (1), p.163-168
Main Authors: Rimsza, Lisa M, Jaramillo, Melba C
Format: Article
Language:English
Subjects:
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - pathology
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Lymphoma, Follicular - genetics
Prognosis
Tumor Microenvironment - genetics
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Summary:As shown with gene expression profiling (GEP), the development and progression of follicular lymphoma (FL) involves complex interactions between neoplastic B cells and the surrounding microenvironment. GEP further reveals that the tumor microenvironment may predict survival in patients with FL and influence the response to therapy and the risk of transformation. Here, we briefly review GEP technology and summarize the role of the tumor microenvironment in FL diagnosis, prognosis, and transformation. Genes expressed by infiltrating T cells and macrophages appear to be the most important predictors of survival, clinical behavior, and outcome. These findings provide a basis for future studies into the pathogenesis and pathophysiology of FL and may ultimately provide guidance in the choice of therapy and the identification of potential therapeutic targets.
ISSN:1520-4391
1520-4383
DOI:10.1182/asheducation-2014.1.163