Heme protein oxidation and lipid peroxidation of tissue homogenates induced by halogenated hydrocarbon, hydroperoxide, and transition metals

Damage of liver, heart, kidney, and spleen caused by spontaneous oxidative reaction or oxidative reactions induced by halogenated hydrocarbon, hydroperoxide, or transition metals was studied in a tissue homogenate system. Both thiobarbituric acid reactive substances (TBARS) and oxidized heme protein...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 1993-09, Vol.41 (9), p.1362-1367
Main Authors: Chen, Hao, Tappel, Al L
Format: Article
Language:English
Subjects:
BAZO
Biological and medical sciences
CATION
CATIONES
COBRE
COEUR
COMPOSE ORGANIQUE
COMPOSE ORGANOBROME
COMPOSE ORGANOCHLORE
COMPUESTO ORGANICO DEL BROMO
COMPUESTO ORGANICO DEL CLORO
COMPUESTOS ORGANICOS
CORAZON
CUIVRE
FER
FOIE
Food industries
Fundamental and applied biological sciences. Psychology
HEMOGLOBINA
HEMOGLOBINE
HIDROCARBUROS HALOGENADOS
HIERRO
HIGADO
HYDROCARBURE HALOGENE
Meat and meat product industries
METAL
METALES
OXIDACION
OXYDATION
PEROXIDACION LIPIDICA
PEROXYDATION DES LIPIDES
RAT
RATA
RATE
REIN
RINONES
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Summary:Damage of liver, heart, kidney, and spleen caused by spontaneous oxidative reaction or oxidative reactions induced by halogenated hydrocarbon, hydroperoxide, or transition metals was studied in a tissue homogenate system. Both thiobarbituric acid reactive substances (TBARS) and oxidized heme proteins (OHP) were measured in oxidatively damaged tissue homogenates. Bromotrichloromethane (CBrCl3), tert-butyl hydroperoxide (TBHP), ferrous iron (Fe2+), and cupric ion (Cu2+) are potent prooxidants. In general, the production of OHP increased more rapidly than the production of TBARS, especially with short incubation periods and low concentrations of prooxidants. The correlation between heme protein oxidation and lipid peroxidation and the merits of using OHP to measure oxidative damage of tissues are discussed
ISSN:0021-8561
1520-5118
DOI:10.1021/jf00033a004