Dietary n-3/long-chain n-3 polyunsaturated fatty acids for prevention of sporadic colorectal tumors: A randomized controlled trial in polypectomized participants

Abstract To address preventive effects of n-3 PUFAs/LC n-3 PUFAs on CRTs, a randomized controlled trial was conducted. One-hundred four experimental group participants were advised to increase intake of n-3 PUFAs, including fish/shell fish, fish oil supplements and perilla oils, and to decrease cons...

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Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2015-03, Vol.94, p.1-11
Main Authors: Tokudome, Shinkan, Kuriki, Kiyonori, Yokoyama, Yoshifumi, Sasaki, Makoto, Joh, Takashi, Kamiya, Takeshi, Cheng, Jinglei, Ogawa, Kumiko, Shirai, Tomoyuki, Imaeda, Nahomi, Goto, Chiho, Tokudome, Yuko, Ichikawa, Hiromitsu, Okuyama, Harumi
Format: Article
Language:English
Subjects:
Advanced Basic Science
Aged
Aged, 80 and over
Case-Control Studies
Colorectal Neoplasms - blood
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - prevention & control
Colorectal Neoplasms - surgery
Colorectal tumors
Dietary Fats, Unsaturated - administration & dosage
Dietary Fats, Unsaturated - blood
Dietary intervention
Endocrinology & Metabolism
Fatty Acids, Omega-3 - administration & dosage
Follow-Up Studies
Humans
Medication Adherence
n-3 polyunsaturated fatty acids
Polypectomized participants
Randomized controlled trial
Treatment Outcome
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Summary:Abstract To address preventive effects of n-3 PUFAs/LC n-3 PUFAs on CRTs, a randomized controlled trial was conducted. One-hundred four experimental group participants were advised to increase intake of n-3 PUFAs, including fish/shell fish, fish oil supplements and perilla oils, and to decrease consumption of n-6 PUFAs and fats/oils as a whole for 24 months. One-hundred one control group participants were only cautioned to reduce consumption of fats/oils as a whole. Random allocation was satisfactorily attained, and participants sufficiently complied with our regimen. Intakes, plasma concentrations, and compositions of the RBC and sigmoid colon membranes of n-3 PUFAs, LC n-3 PUFAs, EPA and DHA increased, and the ratios of n-6 PUFAs/n-3 PUFAs and AA/LC n-3 PUFAs decreased without any adverse response. Twenty-four months after the intervention, the multivariate-adjusted hazard ratio (95% confidence intervals) was estimated to be 0.805 (0.536–1.209) with a signal towards the reduced CRT incidence.
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2014.09.001