Latent learning in End Stage Renal Disease (ESRD)

Abstract Cognitive functions such as attention and memory are known to be impaired in End Stage Renal Disease (ESRD), but the sites of the neural changes underlying these impairments are uncertain. Patients and controls took part in a latent learning task, which had previously shown a dissociation b...

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Bibliographic Details
Published in:Physiology & behavior 2015-04, Vol.142, p.42-47
Main Authors: Jones, Daniel J.W, Butler, Laurie T, Harris, John P, Vaux, Emma C
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cognitive impairment
Comorbidity
Cortical dysfunction
End Stage Renal Disease (ESRD)
Face
Humans
Hypertension - complications
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - psychology
Kidney Failure, Chronic - therapy
Learning
Middle Aged
Photic Stimulation
Psychiatry
Psychological Tests
Random Allocation
Reading
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Summary:Abstract Cognitive functions such as attention and memory are known to be impaired in End Stage Renal Disease (ESRD), but the sites of the neural changes underlying these impairments are uncertain. Patients and controls took part in a latent learning task, which had previously shown a dissociation between patients with Parkinson's disease and those with medial temporal damage. ESRD patients (n = 24) and age and education-matched controls (n = 24) were randomly assigned to either an exposed or unexposed condition. In Phase 1 of the task, participants learned that a cue (word) on the back of a schematic head predicted that the subsequently seen face would be smiling. For the exposed (but not unexposed) condition, an additional (irrelevant) colour cue was shown during presentation. In Phase 2, a different association, between colour and facial expression, was learned. Instructions were the same for each phase: participants had to predict whether the subsequently viewed face was going to be happy or sad. No difference in error rate between the groups was found in Phase 1, suggesting that patients and controls learned at a similar rate. However, in Phase 2, a significant interaction was found between group and condition, with exposed controls performing significantly worse than unexposed (therefore demonstrating learned irrelevance). In contrast, exposed patients made a similar number of errors to unexposed in Phase 2. The pattern of results in ESRD was different from that previously found in Parkinson's disease, suggesting a different neural origin.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2015.01.033