Comparison of larval and adult P-450 activity levels for alkaloid metabolism in desert Drosophila

The cytochrome P-450 monooxygenase system has been implicated in plant utilization by at least three species of Drosophila (D. nigrospiracula, D. mettleri, and D. mojavensis) that are endemic to the Sonoran Desert of the southwestern United States and northwestern Mexico. Basal and induced levels of...

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Bibliographic Details
Published in:Journal of chemical ecology 1994-08, Vol.20 (8), p.1893-1906
Main Authors: Danielson, P.B. (University of Denver, Denver, CO.), Frank, M.R, Fogleman, J.C
Format: Article
Language:English
Subjects:
ADULTE
ADULTOS
ALCALOIDE
ALCALOIDES
Biochemistry. Physiology. Immunology
Biological and medical sciences
CITOCROMOS
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CONTROL DE INSECTOS
CYTOCHROME
Diptera
DROSOPHILA
Drosophilidae
ESTADOS DEL SUR (EUA)
ETATS DU SUD (EU)
Fundamental and applied biological sciences. Psychology
Insecta
Invertebrates
LARVAS
LARVE
LUTTE ANTIINSECTE
METABOLISME
METABOLISMO
METALLOPROTEINE
METALPROTEINAS
Physiology. Development
RESISTANCE AUX ORGANISMES NUISIBLES
RESISTENCIA A LAS PLAGAS
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Summary:The cytochrome P-450 monooxygenase system has been implicated in plant utilization by at least three species of Drosophila (D. nigrospiracula, D. mettleri, and D. mojavensis) that are endemic to the Sonoran Desert of the southwestern United States and northwestern Mexico. Basal and induced levels of total cytochrome P450 were determined for third-instar and decapitated 2- to 5-day post eclosion adults of the three desert species. Total P450 levels, both basal and induced for all species assayed, were significantly higher for adults than for larvae by up to 20-fold. On a per organism basis, the levels of in vitro metabolism of the cactus alkaloid, carnegine, and patterns of response to induction by cactus tissue for adult desert Drosophila approximated those of larvae. Induction by phenobarbital, however, resulted in levels of in vitro carnegine metabolism that were up to 5.6-fold higher in adults than in larvae
ISSN:0098-0331
1573-1561
DOI:10.1007/BF02066231