Hemoglobin levels and circulating blasts are two easily evaluable diagnostic parameters highly predictive of leukemic transformation in primary myelofibrosis

Highlights • We presented an easy score to predict leukemic transformation in PMF. • The model is based on anemia and circulating blasts. • Two groups were defined, low (none/one parameter) vs high risk (both parameters). • The study included a validation cohort. • These data could be useful for ins...

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Bibliographic Details
Published in:Leukemia research 2015-03, Vol.39 (3), p.314-317
Main Authors: Rago, Angela, Latagliata, Roberto, Montanaro, Marco, Montefusco, Enrico, Andriani, Alessandro, Crescenzi, Sabrina Leonetti, Mecarocci, Sergio, Spirito, Francesca, Spadea, Antonio, Recine, Umberto, Cicconi, Laura, Avvisati, Giuseppe, Cedrone, Michele, Breccia, Massimo, Porrini, Raffaele, Villivà, Nicoletta, De Gregoris, Cinzia, Alimena, Giuliana, D’Arcangelo, Enzo, Guglielmelli, Paola, Lo-Coco, Francesco, Vannucchi, Alessandro, Cimino, Giuseppe
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anemia
Anemia - physiopathology
Blast Crisis
Cell Transformation, Neoplastic - metabolism
Cell Transformation, Neoplastic - pathology
Circulating blasts
Female
Follow-Up Studies
Hematology, Oncology and Palliative Medicine
Hemoglobins - analysis
Humans
Leukaemic transformation
Leukemic transformation risk
Male
Middle Aged
Neoplastic Cells, Circulating - pathology
Primary myelofibrosis
Primary Myelofibrosis - blood
Primary Myelofibrosis - diagnosis
Prognosis
Retrospective Studies
Survival Rate
Validation Studies as Topic
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Description
Summary:Highlights • We presented an easy score to predict leukemic transformation in PMF. • The model is based on anemia and circulating blasts. • Two groups were defined, low (none/one parameter) vs high risk (both parameters). • The study included a validation cohort. • These data could be useful for institutions of developing countries.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2015.01.001