Changes in the TNF-alpha/IL-10 ratio in hyperglycemia-associated pregnancies

Highlights • TNF-α/IL-10 ratio is associated with the severity of hyperglycemia during gestation. • Plasma TNF-α levels are higher in pregnant women with gestational diabetes. • Plasma IL-10 levels are lower in pregnant women with type 2 diabetes. • Placental TNF-α levels are higher in pregnant wome...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2015-03, Vol.107 (3), p.362-369
Main Authors: Moreli, Jusciele B, Corrêa-Silva, Simone, Damasceno, Débora C, Sinzato, Yuri K, Lorenzon-Ojea, Aline R, Borbely, Alexandre U, Rudge, Marilza V.C, Bevilacqua, Estela, Calderon, Iracema M.P
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - analysis
Cross-Sectional Studies
Cytokines
Cytokines - analysis
Cytokines - blood
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetes, Gestational - blood
Diabetes, Gestational - epidemiology
Endocrinology & Metabolism
Female
Humans
Hyperglycemia - blood
Hyperglycemia - epidemiology
Interleukin-10 - analysis
Interleukin-10 - blood
Mild gestational hyperglycemia
Placenta
Placenta - chemistry
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - epidemiology
Pregnancy in Diabetics - blood
Pregnancy in Diabetics - epidemiology
Pregnancy Outcome - epidemiology
Tumor Necrosis Factor-alpha - analysis
Tumor Necrosis Factor-alpha - blood
Young Adult
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Summary:Highlights • TNF-α/IL-10 ratio is associated with the severity of hyperglycemia during gestation. • Plasma TNF-α levels are higher in pregnant women with gestational diabetes. • Plasma IL-10 levels are lower in pregnant women with type 2 diabetes. • Placental TNF-α levels are higher in pregnant women with type 2 diabetes. • TNF-α/IL-10 ratio during gestation should be considered as a key factor in clinical practice.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2015.01.005