Quantitative measurements of brain iron deposition in cirrhotic patients using susceptibility mapping

Background Susceptibility-weighted imaging (SWI) has been used to detect micro-bleeds and iron deposits in the brain. However, no reports have been published on the application of SWI in studying iron changes in the brain of cirrhotic patients. Purpose To compare the susceptibility of different brai...

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Bibliographic Details
Published in:Acta radiologica (1987) 2015-03, Vol.56 (3), p.339-346
Main Authors: Xia, Shuang, Zheng, Gang, Shen, Wen, Liu, Saifeng, Zhang, Long Jiang, Haacke, E Mark, Lu, Guang Ming
Format: Article
Language:English
Subjects:
Adult
Biomarkers - analysis
Brain - pathology
Brain Chemistry
Brain Diseases - etiology
Brain Diseases - pathology
Brain Mapping - methods
Cadaver
Disease Susceptibility - blood
Female
Humans
Iron - analysis
Liver Cirrhosis - blood
Liver Cirrhosis - complications
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests - statistics & numerical data
Reference Values
Retrospective Studies
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Summary:Background Susceptibility-weighted imaging (SWI) has been used to detect micro-bleeds and iron deposits in the brain. However, no reports have been published on the application of SWI in studying iron changes in the brain of cirrhotic patients. Purpose To compare the susceptibility of different brain structures in cirrhotic patients with that in healthy controls and to evaluate susceptibility as a potential biomarker and correlate the measured susceptibility and cadaveric brain iron concentration for a variety of brain structures. Material and Methods Forty-three cirrhotic patients (27 men, 16 women; mean age, 50 ± 9 years) and 34 age- and sex-matched healthy controls (22 men, 12 women; mean age, 47 ± 7 years) were included in this retrospective study. Susceptibility was measured in the frontal white matter, basal ganglia, midbrain, and dentate nucleus and compared with results gathered from two postmortem brain studies. Correlation between susceptibility and clinical biomarkers and neuropsychiatric tests scores was calculated. Results In cirrhotic patients, the susceptibility of left frontal white matter, bilateral caudate head, and right substantia nigra was higher than that in healthy controls (P 
ISSN:0284-1851
1600-0455
DOI:10.1177/0284185114525374