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Quantitative measurements of brain iron deposition in cirrhotic patients using susceptibility mapping
Background Susceptibility-weighted imaging (SWI) has been used to detect micro-bleeds and iron deposits in the brain. However, no reports have been published on the application of SWI in studying iron changes in the brain of cirrhotic patients. Purpose To compare the susceptibility of different brai...
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| Published in: | Acta radiologica (1987) 2015-03, Vol.56 (3), p.339-346 |
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| Main Authors: | , , , , , , |
| Format: | Article |
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| cited_by | cdi_FETCH-LOGICAL-c337t-f4124de9484eec10153b40a2f7f73e8e278fcc31a6d52a986b3ee334f32839723 |
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| container_end_page | 346 |
| container_issue | 3 |
| container_start_page | 339 |
| container_title | Acta radiologica (1987) |
| container_volume | 56 |
| creator | Xia, Shuang Zheng, Gang Shen, Wen Liu, Saifeng Zhang, Long Jiang Haacke, E Mark Lu, Guang Ming |
| description | Background
Susceptibility-weighted imaging (SWI) has been used to detect micro-bleeds and iron deposits in the brain. However, no reports have been published on the application of SWI in studying iron changes in the brain of cirrhotic patients.
Purpose
To compare the susceptibility of different brain structures in cirrhotic patients with that in healthy controls and to evaluate susceptibility as a potential biomarker and correlate the measured susceptibility and cadaveric brain iron concentration for a variety of brain structures.
Material and Methods
Forty-three cirrhotic patients (27 men, 16 women; mean age, 50 ± 9 years) and 34 age- and sex-matched healthy controls (22 men, 12 women; mean age, 47 ± 7 years) were included in this retrospective study. Susceptibility was measured in the frontal white matter, basal ganglia, midbrain, and dentate nucleus and compared with results gathered from two postmortem brain studies. Correlation between susceptibility and clinical biomarkers and neuropsychiatric tests scores was calculated.
Results
In cirrhotic patients, the susceptibility of left frontal white matter, bilateral caudate head, and right substantia nigra was higher than that in healthy controls (P |
| doi_str_mv | 10.1177/0284185114525374 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1658705058</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0284185114525374</sage_id><sourcerecordid>1658705058</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-f4124de9484eec10153b40a2f7f73e8e278fcc31a6d52a986b3ee334f32839723</originalsourceid><addsrcrecordid>eNp1kMtLAzEQxoMotlbvniRHL6t5btKjFF8giKDnJbs7W1O6mzUPof-9qa0eBE8zzPy-j5kPoXNKrihV6powLaiWlArJJFfiAE1pSUhBhJSHaLpdF9v9BJ2EsCKEMiXpMZowUYqyZHKK4CWZIdpoov0E3IMJyUMPQwzYdbj2xg7YejfgFkYXbLS5zaPGev_uom3wmJXfeAp2WOKQQgNjtLVd27jBvRnHPD5FR51ZBzjb1xl6u7t9XTwUT8_3j4ubp6LhXMWiE5SJFuZCC4CGEip5LYhhneoUBw1M6a5pODVlK5mZ67LmAJyLjjPN54rxGbrc-Y7efSQIseptvme9NgO4FCpaSq2IJFJnlOzQxrsQPHTV6G1v_KaipNqGW_0NN0su9u6p7qH9FfykmYFiBwSzhGrlkh_yt_8bfgEpYIMN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1658705058</pqid></control><display><type>article</type><title>Quantitative measurements of brain iron deposition in cirrhotic patients using susceptibility mapping</title><source>SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list)</source><creator>Xia, Shuang ; Zheng, Gang ; Shen, Wen ; Liu, Saifeng ; Zhang, Long Jiang ; Haacke, E Mark ; Lu, Guang Ming</creator><creatorcontrib>Xia, Shuang ; Zheng, Gang ; Shen, Wen ; Liu, Saifeng ; Zhang, Long Jiang ; Haacke, E Mark ; Lu, Guang Ming</creatorcontrib><description>Background
Susceptibility-weighted imaging (SWI) has been used to detect micro-bleeds and iron deposits in the brain. However, no reports have been published on the application of SWI in studying iron changes in the brain of cirrhotic patients.
Purpose
To compare the susceptibility of different brain structures in cirrhotic patients with that in healthy controls and to evaluate susceptibility as a potential biomarker and correlate the measured susceptibility and cadaveric brain iron concentration for a variety of brain structures.
Material and Methods
Forty-three cirrhotic patients (27 men, 16 women; mean age, 50 ± 9 years) and 34 age- and sex-matched healthy controls (22 men, 12 women; mean age, 47 ± 7 years) were included in this retrospective study. Susceptibility was measured in the frontal white matter, basal ganglia, midbrain, and dentate nucleus and compared with results gathered from two postmortem brain studies. Correlation between susceptibility and clinical biomarkers and neuropsychiatric tests scores was calculated.
Results
In cirrhotic patients, the susceptibility of left frontal white matter, bilateral caudate head, and right substantia nigra was higher than that in healthy controls (P < 0.05). There was a positive correlation between susceptibility and iron concentration from one postmortem brain study (r = 0.835, P = 0.01) in eight deep grey matter structures and another in five brain structures (r = 0.900, P = 0.03). The susceptibility of right caudate head (r = 0.402) and left caudate head (r = 0.408) correlated with neuropsychological test scores (both P < 0.05).
Conclusion
Abnormal iron deposits occur in cirrhotic patients and abnormal susceptibility of some brain regions appears to reflect neurocognitive changes.</description><identifier>ISSN: 0284-1851</identifier><identifier>EISSN: 1600-0455</identifier><identifier>DOI: 10.1177/0284185114525374</identifier><identifier>PMID: 24646625</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Biomarkers - analysis ; Brain - pathology ; Brain Chemistry ; Brain Diseases - etiology ; Brain Diseases - pathology ; Brain Mapping - methods ; Cadaver ; Disease Susceptibility - blood ; Female ; Humans ; Iron - analysis ; Liver Cirrhosis - blood ; Liver Cirrhosis - complications ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests - statistics & numerical data ; Reference Values ; Retrospective Studies</subject><ispartof>Acta radiologica (1987), 2015-03, Vol.56 (3), p.339-346</ispartof><rights>The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-f4124de9484eec10153b40a2f7f73e8e278fcc31a6d52a986b3ee334f32839723</citedby><cites>FETCH-LOGICAL-c337t-f4124de9484eec10153b40a2f7f73e8e278fcc31a6d52a986b3ee334f32839723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24646625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xia, Shuang</creatorcontrib><creatorcontrib>Zheng, Gang</creatorcontrib><creatorcontrib>Shen, Wen</creatorcontrib><creatorcontrib>Liu, Saifeng</creatorcontrib><creatorcontrib>Zhang, Long Jiang</creatorcontrib><creatorcontrib>Haacke, E Mark</creatorcontrib><creatorcontrib>Lu, Guang Ming</creatorcontrib><title>Quantitative measurements of brain iron deposition in cirrhotic patients using susceptibility mapping</title><title>Acta radiologica (1987)</title><addtitle>Acta Radiol</addtitle><description>Background
Susceptibility-weighted imaging (SWI) has been used to detect micro-bleeds and iron deposits in the brain. However, no reports have been published on the application of SWI in studying iron changes in the brain of cirrhotic patients.
Purpose
To compare the susceptibility of different brain structures in cirrhotic patients with that in healthy controls and to evaluate susceptibility as a potential biomarker and correlate the measured susceptibility and cadaveric brain iron concentration for a variety of brain structures.
Material and Methods
Forty-three cirrhotic patients (27 men, 16 women; mean age, 50 ± 9 years) and 34 age- and sex-matched healthy controls (22 men, 12 women; mean age, 47 ± 7 years) were included in this retrospective study. Susceptibility was measured in the frontal white matter, basal ganglia, midbrain, and dentate nucleus and compared with results gathered from two postmortem brain studies. Correlation between susceptibility and clinical biomarkers and neuropsychiatric tests scores was calculated.
Results
In cirrhotic patients, the susceptibility of left frontal white matter, bilateral caudate head, and right substantia nigra was higher than that in healthy controls (P < 0.05). There was a positive correlation between susceptibility and iron concentration from one postmortem brain study (r = 0.835, P = 0.01) in eight deep grey matter structures and another in five brain structures (r = 0.900, P = 0.03). The susceptibility of right caudate head (r = 0.402) and left caudate head (r = 0.408) correlated with neuropsychological test scores (both P < 0.05).
Conclusion
Abnormal iron deposits occur in cirrhotic patients and abnormal susceptibility of some brain regions appears to reflect neurocognitive changes.</description><subject>Adult</subject><subject>Biomarkers - analysis</subject><subject>Brain - pathology</subject><subject>Brain Chemistry</subject><subject>Brain Diseases - etiology</subject><subject>Brain Diseases - pathology</subject><subject>Brain Mapping - methods</subject><subject>Cadaver</subject><subject>Disease Susceptibility - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Iron - analysis</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - complications</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><issn>0284-1851</issn><issn>1600-0455</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1kMtLAzEQxoMotlbvniRHL6t5btKjFF8giKDnJbs7W1O6mzUPof-9qa0eBE8zzPy-j5kPoXNKrihV6powLaiWlArJJFfiAE1pSUhBhJSHaLpdF9v9BJ2EsCKEMiXpMZowUYqyZHKK4CWZIdpoov0E3IMJyUMPQwzYdbj2xg7YejfgFkYXbLS5zaPGev_uom3wmJXfeAp2WOKQQgNjtLVd27jBvRnHPD5FR51ZBzjb1xl6u7t9XTwUT8_3j4ubp6LhXMWiE5SJFuZCC4CGEip5LYhhneoUBw1M6a5pODVlK5mZ67LmAJyLjjPN54rxGbrc-Y7efSQIseptvme9NgO4FCpaSq2IJFJnlOzQxrsQPHTV6G1v_KaipNqGW_0NN0su9u6p7qH9FfykmYFiBwSzhGrlkh_yt_8bfgEpYIMN</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Xia, Shuang</creator><creator>Zheng, Gang</creator><creator>Shen, Wen</creator><creator>Liu, Saifeng</creator><creator>Zhang, Long Jiang</creator><creator>Haacke, E Mark</creator><creator>Lu, Guang Ming</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201503</creationdate><title>Quantitative measurements of brain iron deposition in cirrhotic patients using susceptibility mapping</title><author>Xia, Shuang ; Zheng, Gang ; Shen, Wen ; Liu, Saifeng ; Zhang, Long Jiang ; Haacke, E Mark ; Lu, Guang Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-f4124de9484eec10153b40a2f7f73e8e278fcc31a6d52a986b3ee334f32839723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Biomarkers - analysis</topic><topic>Brain - pathology</topic><topic>Brain Chemistry</topic><topic>Brain Diseases - etiology</topic><topic>Brain Diseases - pathology</topic><topic>Brain Mapping - methods</topic><topic>Cadaver</topic><topic>Disease Susceptibility - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Iron - analysis</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - complications</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Shuang</creatorcontrib><creatorcontrib>Zheng, Gang</creatorcontrib><creatorcontrib>Shen, Wen</creatorcontrib><creatorcontrib>Liu, Saifeng</creatorcontrib><creatorcontrib>Zhang, Long Jiang</creatorcontrib><creatorcontrib>Haacke, E Mark</creatorcontrib><creatorcontrib>Lu, Guang Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta radiologica (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Shuang</au><au>Zheng, Gang</au><au>Shen, Wen</au><au>Liu, Saifeng</au><au>Zhang, Long Jiang</au><au>Haacke, E Mark</au><au>Lu, Guang Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative measurements of brain iron deposition in cirrhotic patients using susceptibility mapping</atitle><jtitle>Acta radiologica (1987)</jtitle><addtitle>Acta Radiol</addtitle><date>2015-03</date><risdate>2015</risdate><volume>56</volume><issue>3</issue><spage>339</spage><epage>346</epage><pages>339-346</pages><issn>0284-1851</issn><eissn>1600-0455</eissn><abstract>Background
Susceptibility-weighted imaging (SWI) has been used to detect micro-bleeds and iron deposits in the brain. However, no reports have been published on the application of SWI in studying iron changes in the brain of cirrhotic patients.
Purpose
To compare the susceptibility of different brain structures in cirrhotic patients with that in healthy controls and to evaluate susceptibility as a potential biomarker and correlate the measured susceptibility and cadaveric brain iron concentration for a variety of brain structures.
Material and Methods
Forty-three cirrhotic patients (27 men, 16 women; mean age, 50 ± 9 years) and 34 age- and sex-matched healthy controls (22 men, 12 women; mean age, 47 ± 7 years) were included in this retrospective study. Susceptibility was measured in the frontal white matter, basal ganglia, midbrain, and dentate nucleus and compared with results gathered from two postmortem brain studies. Correlation between susceptibility and clinical biomarkers and neuropsychiatric tests scores was calculated.
Results
In cirrhotic patients, the susceptibility of left frontal white matter, bilateral caudate head, and right substantia nigra was higher than that in healthy controls (P < 0.05). There was a positive correlation between susceptibility and iron concentration from one postmortem brain study (r = 0.835, P = 0.01) in eight deep grey matter structures and another in five brain structures (r = 0.900, P = 0.03). The susceptibility of right caudate head (r = 0.402) and left caudate head (r = 0.408) correlated with neuropsychological test scores (both P < 0.05).
Conclusion
Abnormal iron deposits occur in cirrhotic patients and abnormal susceptibility of some brain regions appears to reflect neurocognitive changes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>24646625</pmid><doi>10.1177/0284185114525374</doi><tpages>8</tpages></addata></record> |
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| ispartof | Acta radiologica (1987), 2015-03, Vol.56 (3), p.339-346 |
| issn | 0284-1851 1600-0455 |
| language | eng |
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| source | SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list) |
| subjects | Adult Biomarkers - analysis Brain - pathology Brain Chemistry Brain Diseases - etiology Brain Diseases - pathology Brain Mapping - methods Cadaver Disease Susceptibility - blood Female Humans Iron - analysis Liver Cirrhosis - blood Liver Cirrhosis - complications Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests - statistics & numerical data Reference Values Retrospective Studies |
| title | Quantitative measurements of brain iron deposition in cirrhotic patients using susceptibility mapping |
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