Possible Role of Free Radical Intermediates in Hepatotoxicity of Hydrazine Derivatives

Hydrazine derivatives constitute a wide group of compounds and have found application in industry, agriculture, and (as therapeutical agents) medicine. In spite of their widely spread use, several hydrazine derivatives arc known to exert hepatotoxic effects and are carcinogenic. Free radical species...

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Bibliographic Details
Published in:Toxicology and industrial health 1993-05, Vol.9 (3), p.529-537
Main Authors: Albano, Emanuele, Goria-Gatti, Lucia, Clot, Paolo, Jannone, Anna, Tomasi, Aldo
Format: Article
Language:English
Subjects:
Animals
Cytochrome P-450 Enzyme System - metabolism
Free Radicals - metabolism
Humans
Hydrazines - toxicity
Liver - drug effects
Liver - enzymology
Liver - metabolism
Microsomes, Liver - drug effects
Microsomes, Liver - enzymology
Microsomes, Liver - metabolism
Oxidation-Reduction
Rats
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Summary:Hydrazine derivatives constitute a wide group of compounds and have found application in industry, agriculture, and (as therapeutical agents) medicine. In spite of their widely spread use, several hydrazine derivatives arc known to exert hepatotoxic effects and are carcinogenic. Free radical species are produced during the hepatic biotransformation ofalkylhydrazines by both rat and humans liver microsomes. Cytochrome P-450 dependent monoxygenase system is responsible for the production of these reactive species and specific cytochrome P-450 isoenzymes appear to catalyze the formation of free radical intermediates. Free radicals generated during the metabolism of alkylhydrazines are capable of inducing oxidative stress in isolated hepatocytes and might contribute to the development of cell injury.
ISSN:0748-2337
1477-0393
DOI:10.1177/074823379300900312