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Possible Role of Free Radical Intermediates in Hepatotoxicity of Hydrazine Derivatives
Hydrazine derivatives constitute a wide group of compounds and have found application in industry, agriculture, and (as therapeutical agents) medicine. In spite of their widely spread use, several hydrazine derivatives arc known to exert hepatotoxic effects and are carcinogenic. Free radical species...
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| Published in: | Toxicology and industrial health 1993-05, Vol.9 (3), p.529-537 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c369t-19fcd9425555da2f6a2feb21018fa849c7c3bb702e1bba13466bee73cec4fcca3 |
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| cites | cdi_FETCH-LOGICAL-c369t-19fcd9425555da2f6a2feb21018fa849c7c3bb702e1bba13466bee73cec4fcca3 |
| container_end_page | 537 |
| container_issue | 3 |
| container_start_page | 529 |
| container_title | Toxicology and industrial health |
| container_volume | 9 |
| creator | Albano, Emanuele Goria-Gatti, Lucia Clot, Paolo Jannone, Anna Tomasi, Aldo |
| description | Hydrazine derivatives constitute a wide group of compounds and have found application in industry, agriculture, and (as therapeutical agents) medicine. In spite of their widely spread use, several hydrazine derivatives arc known to exert hepatotoxic effects and are carcinogenic.
Free radical species are produced during the hepatic biotransformation ofalkylhydrazines by both rat and humans liver microsomes. Cytochrome P-450 dependent monoxygenase system is responsible for the production of these reactive species and specific cytochrome P-450 isoenzymes appear to catalyze the formation of free radical intermediates.
Free radicals generated during the metabolism of alkylhydrazines are capable of inducing oxidative stress in isolated hepatocytes and might contribute to the development of cell injury. |
| doi_str_mv | 10.1177/074823379300900312 |
| format | article |
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Free radical species are produced during the hepatic biotransformation ofalkylhydrazines by both rat and humans liver microsomes. Cytochrome P-450 dependent monoxygenase system is responsible for the production of these reactive species and specific cytochrome P-450 isoenzymes appear to catalyze the formation of free radical intermediates.
Free radicals generated during the metabolism of alkylhydrazines are capable of inducing oxidative stress in isolated hepatocytes and might contribute to the development of cell injury.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/074823379300900312</identifier><identifier>PMID: 8367892</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Cytochrome P-450 Enzyme System - metabolism ; Free Radicals - metabolism ; Humans ; Hydrazines - toxicity ; Liver - drug effects ; Liver - enzymology ; Liver - metabolism ; Microsomes, Liver - drug effects ; Microsomes, Liver - enzymology ; Microsomes, Liver - metabolism ; Oxidation-Reduction ; Rats</subject><ispartof>Toxicology and industrial health, 1993-05, Vol.9 (3), p.529-537</ispartof><rights>1993 SAGE Publications</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-19fcd9425555da2f6a2feb21018fa849c7c3bb702e1bba13466bee73cec4fcca3</citedby><cites>FETCH-LOGICAL-c369t-19fcd9425555da2f6a2feb21018fa849c7c3bb702e1bba13466bee73cec4fcca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/074823379300900312$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/074823379300900312$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21824,27901,27902,45058,45446</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8367892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albano, Emanuele</creatorcontrib><creatorcontrib>Goria-Gatti, Lucia</creatorcontrib><creatorcontrib>Clot, Paolo</creatorcontrib><creatorcontrib>Jannone, Anna</creatorcontrib><creatorcontrib>Tomasi, Aldo</creatorcontrib><title>Possible Role of Free Radical Intermediates in Hepatotoxicity of Hydrazine Derivatives</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>Hydrazine derivatives constitute a wide group of compounds and have found application in industry, agriculture, and (as therapeutical agents) medicine. In spite of their widely spread use, several hydrazine derivatives arc known to exert hepatotoxic effects and are carcinogenic.
Free radical species are produced during the hepatic biotransformation ofalkylhydrazines by both rat and humans liver microsomes. Cytochrome P-450 dependent monoxygenase system is responsible for the production of these reactive species and specific cytochrome P-450 isoenzymes appear to catalyze the formation of free radical intermediates.
Free radicals generated during the metabolism of alkylhydrazines are capable of inducing oxidative stress in isolated hepatocytes and might contribute to the development of cell injury.</description><subject>Animals</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Free Radicals - metabolism</subject><subject>Humans</subject><subject>Hydrazines - toxicity</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Microsomes, Liver - drug effects</subject><subject>Microsomes, Liver - enzymology</subject><subject>Microsomes, Liver - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Rats</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNp9kN9LwzAQx4Moc07_AUHok2_V_GiT5lGmc4OBIuprSdOrZHTNTNLh_OtN2fBF8ODuOO5zX7gvQpcE3xAixC0WWUEZE5JhLDFmhB6hMcmESDGT7BiNByAdiFN05v0KY8x5TkdoVDAuCknH6P3Zem-qFpIXG4ttkpmDOKjaaNUmiy6AW0NtVACfmC6Zw0YFG-yX0SbsBn6-q536Nh0k9-DMVgWzBX-OThrVerg49Al6mz28Tufp8ulxMb1bpppxGVIiG13LjOYxakUbHhMqSjApGlVkUgvNqkpgCqSqFGEZ5xWAYBp01mit2ARd73U3zn724EO5Nl5D26oObO9LwvNCSJxHkO5B7eLDDppy48xauV1JcDmYWf41Mx5dHdT7Kprwe3JwL-5v93uvPqBc2d518dn_FH8ABwp9sA</recordid><startdate>19930501</startdate><enddate>19930501</enddate><creator>Albano, Emanuele</creator><creator>Goria-Gatti, Lucia</creator><creator>Clot, Paolo</creator><creator>Jannone, Anna</creator><creator>Tomasi, Aldo</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19930501</creationdate><title>Possible Role of Free Radical Intermediates in Hepatotoxicity of Hydrazine Derivatives</title><author>Albano, Emanuele ; Goria-Gatti, Lucia ; Clot, Paolo ; Jannone, Anna ; Tomasi, Aldo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-19fcd9425555da2f6a2feb21018fa849c7c3bb702e1bba13466bee73cec4fcca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Free Radicals - metabolism</topic><topic>Humans</topic><topic>Hydrazines - toxicity</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Microsomes, Liver - drug effects</topic><topic>Microsomes, Liver - enzymology</topic><topic>Microsomes, Liver - metabolism</topic><topic>Oxidation-Reduction</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albano, Emanuele</creatorcontrib><creatorcontrib>Goria-Gatti, Lucia</creatorcontrib><creatorcontrib>Clot, Paolo</creatorcontrib><creatorcontrib>Jannone, Anna</creatorcontrib><creatorcontrib>Tomasi, Aldo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology and industrial health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Albano, Emanuele</au><au>Goria-Gatti, Lucia</au><au>Clot, Paolo</au><au>Jannone, Anna</au><au>Tomasi, Aldo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible Role of Free Radical Intermediates in Hepatotoxicity of Hydrazine Derivatives</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>1993-05-01</date><risdate>1993</risdate><volume>9</volume><issue>3</issue><spage>529</spage><epage>537</epage><pages>529-537</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>Hydrazine derivatives constitute a wide group of compounds and have found application in industry, agriculture, and (as therapeutical agents) medicine. In spite of their widely spread use, several hydrazine derivatives arc known to exert hepatotoxic effects and are carcinogenic.
Free radical species are produced during the hepatic biotransformation ofalkylhydrazines by both rat and humans liver microsomes. Cytochrome P-450 dependent monoxygenase system is responsible for the production of these reactive species and specific cytochrome P-450 isoenzymes appear to catalyze the formation of free radical intermediates.
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| fulltext | fulltext |
| identifier | ISSN: 0748-2337 |
| ispartof | Toxicology and industrial health, 1993-05, Vol.9 (3), p.529-537 |
| issn | 0748-2337 1477-0393 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16587905 |
| source | SAGE Complete Deep Backfile Purchase 2012 |
| subjects | Animals Cytochrome P-450 Enzyme System - metabolism Free Radicals - metabolism Humans Hydrazines - toxicity Liver - drug effects Liver - enzymology Liver - metabolism Microsomes, Liver - drug effects Microsomes, Liver - enzymology Microsomes, Liver - metabolism Oxidation-Reduction Rats |
| title | Possible Role of Free Radical Intermediates in Hepatotoxicity of Hydrazine Derivatives |
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