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Regional brain activity change predicts responsiveness to treatment for stuttering in adults

•PET study on two behavioral treatments for chronic developmental stuttering in adults.•Logistic regression isolated brain activity in adults who succeed and fail to respond positively to stuttering treatment.•Changes in brain activity during speaking tasks and eyes-closed rest equally identified tr...

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Bibliographic Details
Published in:Brain and language 2013-12, Vol.127 (3), p.510-519
Main Authors: Ingham, Roger J., Wang, Yuedong, Ingham, Janis C., Bothe, Anne K., Grafton, Scott T.
Format: Article
Language:English
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Summary:•PET study on two behavioral treatments for chronic developmental stuttering in adults.•Logistic regression isolated brain activity in adults who succeed and fail to respond positively to stuttering treatment.•Changes in brain activity during speaking tasks and eyes-closed rest equally identified treatment success and failure.•Changes in L. putamen activation levels identified 85% of treatment responders or nonresponders.•Results suggest ways that stuttering treatment might be modified to increase the likelihood of a positive outcome. Developmental stuttering is known to be associated with aberrant brain activity, but there is no evidence that this knowledge has benefited stuttering treatment. This study investigated whether brain activity could predict progress during stuttering treatment for 21 dextral adults who stutter (AWS). They received one of two treatment programs that included periodic H215O PET scanning (during oral reading, monologue, and eyes-closed rest conditions). All participants successfully completed an initial treatment phase and then entered a phase designed to transfer treatment gains; 9/21 failed to complete this latter phase. The 12 pass and 9 fail participants were similar on speech and neural system variables before treatment, and similar in speech performance after the initial phase of their treatment. At the end of the initial treatment phase, however, decreased activation within a single region, L. putamen, in all 3 scanning conditions was highly predictive of successful treatment progress.
ISSN:0093-934X
1090-2155
DOI:10.1016/j.bandl.2013.10.007