HEPES-involved hydrothermal synthesis of Fe sub(3)O sub(4) nanoparticles and their biological application

A simple one-step hydrothermal route was developed for the synthesis of magnetite (Fe sub(3)O sub(4)) nanoparticles in HEPES solution, using FeCl sub(2) as the Fe(ii) precursor. It was found that HEPES played an important role in the fabrication of Fe sub(3)O sub(4) nanoparticles, where HEPES could...

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Bibliographic Details
Published in:RSC advances 2014-12, Vol.5 (7), p.5059-5067
Main Authors: Li, Hui, Lu, Zhong, Cheng, Gang, Rong, Kaifeng, Chen, Fengxi, Chen, Rong
Format: Article
Language:English
Subjects:
Anions
Antibacterial properties
Gold
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Silver
Synthesis
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Summary:A simple one-step hydrothermal route was developed for the synthesis of magnetite (Fe sub(3)O sub(4)) nanoparticles in HEPES solution, using FeCl sub(2) as the Fe(ii) precursor. It was found that HEPES played an important role in the fabrication of Fe sub(3)O sub(4) nanoparticles, where HEPES could act as a weak antioxidant to prevent the complete oxidation of Fe(ii) to Fe(iii). The possible formation mechanism of HEPES-coated Fe sub(3)O sub(4) nanomaterials was also discussed. In the reaction system, the influence of inorganic anions on the morphologies of Fe sub(3)O sub(4) nanostructures was also investigated. The as-synthesized spherical Fe sub(3)O sub(4) nanoparticles with a concentration of 5-100 mu g mL super(-1) exhibited nontoxicity towards HUVEC normal cells, indicating their potential application in biology. Combining the preparation of Ag and Au nanoparticles in HEPES solution, Ag/Fe sub(3)O sub(4) and Au/Fe sub(3)O sub(4) nanocomposites were successfully synthesized by a two-step method, which showed excellent antibacterial properties against S. aureus. Furthermore, the Ag/Fe sub(3)O sub(4) and Au/Fe sub(3)O sub(4) nanocomposites could be recycled and reused due to their superparamagnetic properties and retained their antibacterial activities.
ISSN:2046-2069
DOI:10.1039/c4ra12536c