Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats

Highlights ► Neonatal exposure to permethrin induces cognitive deficits in pre-senescent rats. ► Spatial working memory was tested in a T-maze-rewarded alternation task. ► The treated rats took longer to choose for a correct arm in comparison to controls. ► Effect of treatment point to an involvemen...

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Bibliographic Details
Published in:Toxicology (Amsterdam) 2013-01, Vol.303 (7), p.162-168
Main Authors: Nasuti, Cinzia, Carloni, Manuel, Fedeli, Donatella, Gabbianelli, Rosita, Di Stefano, Antonio, Laura Serafina, Cerasa, Silva, Isabel, Domingues, Valentina, Ciccocioppo, Roberto
Format: Article
Language:English
Subjects:
3-Phenoxybenzoic acid
adulthood
adverse effects
Age Factors
animal models
Animals
Benzoates - urine
Brain
cognition
Cognition Disorders - chemically induced
Control equipment
Corpus Striatum - drug effects
Corpus Striatum - metabolism
cortex
Dopamine
Dopamine - metabolism
Early life exposure
Emergency
Exposure
feeding behavior
Female
Hippocampus
Hippocampus - drug effects
Hippocampus - metabolism
Insecticides - administration & dosage
Insecticides - toxicity
lipid peroxidation
locomotion
Male
Maze Learning - drug effects
memory
Memory, Short-Term - drug effects
Monoamines
neurodegenerative diseases
no observed adverse effect level
norepinephrine
Norepinephrine - metabolism
Permethrin
Permethrin - administration & dosage
Permethrin - toxicity
Prefrontal Cortex - drug effects
Prefrontal Cortex - metabolism
pyrethrins
Rat
Rats
Rats, Wistar
risk factors
serotonin
Serotonin - metabolism
Spatial working memory
T-maze
Tasks
Time Factors
Toxicity
toxicology
urine
weight gain
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Summary:Highlights ► Neonatal exposure to permethrin induces cognitive deficits in pre-senescent rats. ► Spatial working memory was tested in a T-maze-rewarded alternation task. ► The treated rats took longer to choose for a correct arm in comparison to controls. ► Effect of treatment point to an involvement of frontal cortico-striatal circuitry. ► 5-HT and NE unbalance in the mPFC were observed in treated rats.
ISSN:0300-483X
1879-3185
DOI:10.1016/j.tox.2012.09.016