Loading…
Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats
Highlights ► Neonatal exposure to permethrin induces cognitive deficits in pre-senescent rats. ► Spatial working memory was tested in a T-maze-rewarded alternation task. ► The treated rats took longer to choose for a correct arm in comparison to controls. ► Effect of treatment point to an involvemen...
Saved in:
| Published in: | Toxicology (Amsterdam) 2013-01, Vol.303 (7), p.162-168 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c602t-785d18e21396c5d4c24c14ad52288911796ef262740fbc32a5e24a6a00d25e823 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c602t-785d18e21396c5d4c24c14ad52288911796ef262740fbc32a5e24a6a00d25e823 |
| container_end_page | 168 |
| container_issue | 7 |
| container_start_page | 162 |
| container_title | Toxicology (Amsterdam) |
| container_volume | 303 |
| creator | Nasuti, Cinzia Carloni, Manuel Fedeli, Donatella Gabbianelli, Rosita Di Stefano, Antonio Laura Serafina, Cerasa Silva, Isabel Domingues, Valentina Ciccocioppo, Roberto |
| description | Highlights ► Neonatal exposure to permethrin induces cognitive deficits in pre-senescent rats. ► Spatial working memory was tested in a T-maze-rewarded alternation task. ► The treated rats took longer to choose for a correct arm in comparison to controls. ► Effect of treatment point to an involvement of frontal cortico-striatal circuitry. ► 5-HT and NE unbalance in the mPFC were observed in treated rats. |
| doi_str_mv | 10.1016/j.tox.2012.09.016 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1660048692</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0300483X12003721</els_id><sourcerecordid>1272739981</sourcerecordid><originalsourceid>FETCH-LOGICAL-c602t-785d18e21396c5d4c24c14ad52288911796ef262740fbc32a5e24a6a00d25e823</originalsourceid><addsrcrecordid>eNqNks1u1TAQhSMEopfCA7ABL9kkjH9iJ0JCQlUpSJVYlErsLF9nUnyb2MFOSu8r8NR1uIUFC2BleeY7xyOfKYrnFCoKVL7eVXO4rRhQVkFb5cqDYkMb1ZacNvXDYgMcoBQN_3JUPElpBwCMC_m4OGKcKlHzdlP8OO17tHMioSdo4rAng-uRTBhHnL9G5wneTiEtEUnwJE1mdmYg30O8dv6KjDiGuCfGd2t3DD6Y0XkkA97gkEhWdy77R_Qz2UaT7yai-fnYFLFM6DHZtRnNnJ4Wj3ozJHx2fx4Xl-9PP598KM8_nX08eXdeWglsLlVTd7RBRnkrbd0Jy4SlwnQ1Y03TUqpaiT2TTAnot5YzUyMTRhqAjtXYMH5cvDr4TjF8WzDNenR5imEwHsOSNJUSQDSy_R9UqPz7qpb_RpliirdtQzNKD6iNIaWIvZ6iG03cawp6DVbvdA5Wr8FqaHWuZM2Le_tlO2L3W_EryQy8PAC9CdpcRZf05UV2qAGoAKVUJt4ciBwN3jiMOlmH3mLnYl4B3QX31wHe_qG2g_POmuEa95h2YYk-p6apTlmjL9bdW1ePMgCuclp3uyvSKQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1272739981</pqid></control><display><type>article</type><title>Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats</title><source>ScienceDirect Freedom Collection</source><creator>Nasuti, Cinzia ; Carloni, Manuel ; Fedeli, Donatella ; Gabbianelli, Rosita ; Di Stefano, Antonio ; Laura Serafina, Cerasa ; Silva, Isabel ; Domingues, Valentina ; Ciccocioppo, Roberto</creator><creatorcontrib>Nasuti, Cinzia ; Carloni, Manuel ; Fedeli, Donatella ; Gabbianelli, Rosita ; Di Stefano, Antonio ; Laura Serafina, Cerasa ; Silva, Isabel ; Domingues, Valentina ; Ciccocioppo, Roberto</creatorcontrib><description>Highlights ► Neonatal exposure to permethrin induces cognitive deficits in pre-senescent rats. ► Spatial working memory was tested in a T-maze-rewarded alternation task. ► The treated rats took longer to choose for a correct arm in comparison to controls. ► Effect of treatment point to an involvement of frontal cortico-striatal circuitry. ► 5-HT and NE unbalance in the mPFC were observed in treated rats.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/j.tox.2012.09.016</identifier><identifier>PMID: 23174539</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>3-Phenoxybenzoic acid ; adulthood ; adverse effects ; Age Factors ; animal models ; Animals ; Benzoates - urine ; Brain ; cognition ; Cognition Disorders - chemically induced ; Control equipment ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; cortex ; Dopamine ; Dopamine - metabolism ; Early life exposure ; Emergency ; Exposure ; feeding behavior ; Female ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - metabolism ; Insecticides - administration & dosage ; Insecticides - toxicity ; lipid peroxidation ; locomotion ; Male ; Maze Learning - drug effects ; memory ; Memory, Short-Term - drug effects ; Monoamines ; neurodegenerative diseases ; no observed adverse effect level ; norepinephrine ; Norepinephrine - metabolism ; Permethrin ; Permethrin - administration & dosage ; Permethrin - toxicity ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - metabolism ; pyrethrins ; Rat ; Rats ; Rats, Wistar ; risk factors ; serotonin ; Serotonin - metabolism ; Spatial working memory ; T-maze ; Tasks ; Time Factors ; Toxicity ; toxicology ; urine ; weight gain</subject><ispartof>Toxicology (Amsterdam), 2013-01, Vol.303 (7), p.162-168</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2012 Elsevier Ireland Ltd</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c602t-785d18e21396c5d4c24c14ad52288911796ef262740fbc32a5e24a6a00d25e823</citedby><cites>FETCH-LOGICAL-c602t-785d18e21396c5d4c24c14ad52288911796ef262740fbc32a5e24a6a00d25e823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23174539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasuti, Cinzia</creatorcontrib><creatorcontrib>Carloni, Manuel</creatorcontrib><creatorcontrib>Fedeli, Donatella</creatorcontrib><creatorcontrib>Gabbianelli, Rosita</creatorcontrib><creatorcontrib>Di Stefano, Antonio</creatorcontrib><creatorcontrib>Laura Serafina, Cerasa</creatorcontrib><creatorcontrib>Silva, Isabel</creatorcontrib><creatorcontrib>Domingues, Valentina</creatorcontrib><creatorcontrib>Ciccocioppo, Roberto</creatorcontrib><title>Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>Highlights ► Neonatal exposure to permethrin induces cognitive deficits in pre-senescent rats. ► Spatial working memory was tested in a T-maze-rewarded alternation task. ► The treated rats took longer to choose for a correct arm in comparison to controls. ► Effect of treatment point to an involvement of frontal cortico-striatal circuitry. ► 5-HT and NE unbalance in the mPFC were observed in treated rats.</description><subject>3-Phenoxybenzoic acid</subject><subject>adulthood</subject><subject>adverse effects</subject><subject>Age Factors</subject><subject>animal models</subject><subject>Animals</subject><subject>Benzoates - urine</subject><subject>Brain</subject><subject>cognition</subject><subject>Cognition Disorders - chemically induced</subject><subject>Control equipment</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>cortex</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Early life exposure</subject><subject>Emergency</subject><subject>Exposure</subject><subject>feeding behavior</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Insecticides - administration & dosage</subject><subject>Insecticides - toxicity</subject><subject>lipid peroxidation</subject><subject>locomotion</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>memory</subject><subject>Memory, Short-Term - drug effects</subject><subject>Monoamines</subject><subject>neurodegenerative diseases</subject><subject>no observed adverse effect level</subject><subject>norepinephrine</subject><subject>Norepinephrine - metabolism</subject><subject>Permethrin</subject><subject>Permethrin - administration & dosage</subject><subject>Permethrin - toxicity</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - metabolism</subject><subject>pyrethrins</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>risk factors</subject><subject>serotonin</subject><subject>Serotonin - metabolism</subject><subject>Spatial working memory</subject><subject>T-maze</subject><subject>Tasks</subject><subject>Time Factors</subject><subject>Toxicity</subject><subject>toxicology</subject><subject>urine</subject><subject>weight gain</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNks1u1TAQhSMEopfCA7ABL9kkjH9iJ0JCQlUpSJVYlErsLF9nUnyb2MFOSu8r8NR1uIUFC2BleeY7xyOfKYrnFCoKVL7eVXO4rRhQVkFb5cqDYkMb1ZacNvXDYgMcoBQN_3JUPElpBwCMC_m4OGKcKlHzdlP8OO17tHMioSdo4rAng-uRTBhHnL9G5wneTiEtEUnwJE1mdmYg30O8dv6KjDiGuCfGd2t3DD6Y0XkkA97gkEhWdy77R_Qz2UaT7yai-fnYFLFM6DHZtRnNnJ4Wj3ozJHx2fx4Xl-9PP598KM8_nX08eXdeWglsLlVTd7RBRnkrbd0Jy4SlwnQ1Y03TUqpaiT2TTAnot5YzUyMTRhqAjtXYMH5cvDr4TjF8WzDNenR5imEwHsOSNJUSQDSy_R9UqPz7qpb_RpliirdtQzNKD6iNIaWIvZ6iG03cawp6DVbvdA5Wr8FqaHWuZM2Le_tlO2L3W_EryQy8PAC9CdpcRZf05UV2qAGoAKVUJt4ciBwN3jiMOlmH3mLnYl4B3QX31wHe_qG2g_POmuEa95h2YYk-p6apTlmjL9bdW1ePMgCuclp3uyvSKQ</recordid><startdate>20130107</startdate><enddate>20130107</enddate><creator>Nasuti, Cinzia</creator><creator>Carloni, Manuel</creator><creator>Fedeli, Donatella</creator><creator>Gabbianelli, Rosita</creator><creator>Di Stefano, Antonio</creator><creator>Laura Serafina, Cerasa</creator><creator>Silva, Isabel</creator><creator>Domingues, Valentina</creator><creator>Ciccocioppo, Roberto</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>8FD</scope><scope>FR3</scope><scope>KR7</scope></search><sort><creationdate>20130107</creationdate><title>Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats</title><author>Nasuti, Cinzia ; Carloni, Manuel ; Fedeli, Donatella ; Gabbianelli, Rosita ; Di Stefano, Antonio ; Laura Serafina, Cerasa ; Silva, Isabel ; Domingues, Valentina ; Ciccocioppo, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c602t-785d18e21396c5d4c24c14ad52288911796ef262740fbc32a5e24a6a00d25e823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>3-Phenoxybenzoic acid</topic><topic>adulthood</topic><topic>adverse effects</topic><topic>Age Factors</topic><topic>animal models</topic><topic>Animals</topic><topic>Benzoates - urine</topic><topic>Brain</topic><topic>cognition</topic><topic>Cognition Disorders - chemically induced</topic><topic>Control equipment</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>cortex</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Early life exposure</topic><topic>Emergency</topic><topic>Exposure</topic><topic>feeding behavior</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Insecticides - administration & dosage</topic><topic>Insecticides - toxicity</topic><topic>lipid peroxidation</topic><topic>locomotion</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>memory</topic><topic>Memory, Short-Term - drug effects</topic><topic>Monoamines</topic><topic>neurodegenerative diseases</topic><topic>no observed adverse effect level</topic><topic>norepinephrine</topic><topic>Norepinephrine - metabolism</topic><topic>Permethrin</topic><topic>Permethrin - administration & dosage</topic><topic>Permethrin - toxicity</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - metabolism</topic><topic>pyrethrins</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>risk factors</topic><topic>serotonin</topic><topic>Serotonin - metabolism</topic><topic>Spatial working memory</topic><topic>T-maze</topic><topic>Tasks</topic><topic>Time Factors</topic><topic>Toxicity</topic><topic>toxicology</topic><topic>urine</topic><topic>weight gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasuti, Cinzia</creatorcontrib><creatorcontrib>Carloni, Manuel</creatorcontrib><creatorcontrib>Fedeli, Donatella</creatorcontrib><creatorcontrib>Gabbianelli, Rosita</creatorcontrib><creatorcontrib>Di Stefano, Antonio</creatorcontrib><creatorcontrib>Laura Serafina, Cerasa</creatorcontrib><creatorcontrib>Silva, Isabel</creatorcontrib><creatorcontrib>Domingues, Valentina</creatorcontrib><creatorcontrib>Ciccocioppo, Roberto</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasuti, Cinzia</au><au>Carloni, Manuel</au><au>Fedeli, Donatella</au><au>Gabbianelli, Rosita</au><au>Di Stefano, Antonio</au><au>Laura Serafina, Cerasa</au><au>Silva, Isabel</au><au>Domingues, Valentina</au><au>Ciccocioppo, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2013-01-07</date><risdate>2013</risdate><volume>303</volume><issue>7</issue><spage>162</spage><epage>168</epage><pages>162-168</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><abstract>Highlights ► Neonatal exposure to permethrin induces cognitive deficits in pre-senescent rats. ► Spatial working memory was tested in a T-maze-rewarded alternation task. ► The treated rats took longer to choose for a correct arm in comparison to controls. ► Effect of treatment point to an involvement of frontal cortico-striatal circuitry. ► 5-HT and NE unbalance in the mPFC were observed in treated rats.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23174539</pmid><doi>10.1016/j.tox.2012.09.016</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-483X |
| ispartof | Toxicology (Amsterdam), 2013-01, Vol.303 (7), p.162-168 |
| issn | 0300-483X 1879-3185 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1660048692 |
| source | ScienceDirect Freedom Collection |
| subjects | 3-Phenoxybenzoic acid adulthood adverse effects Age Factors animal models Animals Benzoates - urine Brain cognition Cognition Disorders - chemically induced Control equipment Corpus Striatum - drug effects Corpus Striatum - metabolism cortex Dopamine Dopamine - metabolism Early life exposure Emergency Exposure feeding behavior Female Hippocampus Hippocampus - drug effects Hippocampus - metabolism Insecticides - administration & dosage Insecticides - toxicity lipid peroxidation locomotion Male Maze Learning - drug effects memory Memory, Short-Term - drug effects Monoamines neurodegenerative diseases no observed adverse effect level norepinephrine Norepinephrine - metabolism Permethrin Permethrin - administration & dosage Permethrin - toxicity Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism pyrethrins Rat Rats Rats, Wistar risk factors serotonin Serotonin - metabolism Spatial working memory T-maze Tasks Time Factors Toxicity toxicology urine weight gain |
| title | Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T15%3A54%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20early%20life%20permethrin%20exposure%20on%20spatial%20working%20memory%20and%20on%20monoamine%20levels%20in%20different%20brain%20areas%20of%20pre-senescent%20rats&rft.jtitle=Toxicology%20(Amsterdam)&rft.au=Nasuti,%20Cinzia&rft.date=2013-01-07&rft.volume=303&rft.issue=7&rft.spage=162&rft.epage=168&rft.pages=162-168&rft.issn=0300-483X&rft.eissn=1879-3185&rft_id=info:doi/10.1016/j.tox.2012.09.016&rft_dat=%3Cproquest_cross%3E1272739981%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c602t-785d18e21396c5d4c24c14ad52288911796ef262740fbc32a5e24a6a00d25e823%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1272739981&rft_id=info:pmid/23174539&rfr_iscdi=true |