A facile approach to hydrophilic, reverse zwitterionic, choline phosphate polymers

2-{2-(Methacryloyloxy)ethyldimethylammonium}ethyl n -butyl phosphate (MBP) was synthesized and polymerized by controlled free radical methods to afford a new set of “reverse zwitterionic” choline phosphate (CP) substituted polymers. The synthesis overcomes prior limitations associated with related C...

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Bibliographic Details
Published in:Polymer chemistry 2015-01, Vol.6 (4), p.525-530
Main Authors: Hu, Gaojie, Parelkar, Sangram S., Emrick, Todd
Format: Article
Language:English
Subjects:
Biocompatibility
Biotechnology
Choline
Copolymers
Free radicals
Monomers
Phosphates
Polymers
Synthesis
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Summary:2-{2-(Methacryloyloxy)ethyldimethylammonium}ethyl n -butyl phosphate (MBP) was synthesized and polymerized by controlled free radical methods to afford a new set of “reverse zwitterionic” choline phosphate (CP) substituted polymers. The synthesis overcomes prior limitations associated with related CP-methacrylates, affording facile access to MBP homopolymers and MBP-containing diblock copolymers. Dynamic light scattering revealed the size of polyMBP in water, while cell culture assays showed polyMBP to have excellent biocompatibility and non-immunogenicity. The facile synthesis of MBP monomer, and the corresponding polymers, opens a new platform towards a diverse set of functional, hydrophilic biocompatible polymers.
ISSN:1759-9954
1759-9962
DOI:10.1039/C4PY01292E