Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts

A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-12, Vol.50 (100), p.15987-15990
Main Authors: Yan, Pu-Cha, Xie, Jian-Hua, Zhang, Xiang-Dong, Chen, Kang, Li, Yuan-Qiang, Zhou, Qi-Lin, Che, Da-Qing
Format: Article
Language:English
Subjects:
Asymmetry
Catalysis
Catalysts
Glyoxylates - chemistry
Hydrogenation
Iridium
Iridium - chemistry
Keto Acids - chemistry
Mandelic Acids - chemistry
Spiro Compounds - chemistry
Stereoisomerism
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Description
Summary:A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc07643e