Anti arthritic and anti inflammatory activity of a cytotoxic protein NN-32 from Indian spectacle cobra (Naja naja) venom in male albino rats

The anti arthritic and anti inflammatory activity of NN-32, a cytotoxic protein from Indian spectacle cobra snake (Naja naja) venom has been studied in Freund's complete adjuvant (FCA) induced arthritis and carrageenan induced anti inflammatory model. NN-32 treatment showed significant decrease...

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Bibliographic Details
Published in:Toxicon (Oxford) 2014-11, Vol.90, p.106-110
Main Authors: Gomes, Antony, Datta, Poulami, Das, Tanaya, Biswas, Ajoy Kumar, Gomes, Aparna
Format: Article
Language:English
Subjects:
Adjuvants
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Arthritis - drug therapy
Carrageenan
Cytokines
Cytotoxic protein
Elapid Venoms - chemistry
Elapidae
Indian Naja naja venom
Male
Males
Naja naja
Proteins
Proteins - pharmacology
Proteins - therapeutic use
Rats
Rheumatoid arthritis
Serums
Spectacles
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Summary:The anti arthritic and anti inflammatory activity of NN-32, a cytotoxic protein from Indian spectacle cobra snake (Naja naja) venom has been studied in Freund's complete adjuvant (FCA) induced arthritis and carrageenan induced anti inflammatory model. NN-32 treatment showed significant decrease in physical and urinary parameters, serum enzymes, serum cytokines levels as compared to arthritic control group of rats. NN-32 treatment recovered carrageenan induced inflammation as compared to control group of rats. The findings showed that the cytotoxic protein NN-32 shares anti arthritic and anti inflammatory activity and thus NN-32 may target complex pathophysiological processes like cancer- arthritis-inflammation. •Anti inflammatory and anti arthritic activity for cytotoxic protein.•Natural Product Research for treatment of arthritis.•Snake venom in the treatment of arthritis.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2014.07.002