5.4L: Late-News Paper: ALA Mediated Metronomic Photodynamic Therapy in Mouse Gliomas Model using Organic Light Emitting Diode

In this study, we presented a pilot study of metronomic photodynamic therapy (mPDT) by the use of organic light emitting diode (OLED) in treating treatment of brain tumor. The low cost, lightweight, and low fluence rate OLED has significant potential in the clinical mPDT applications. In this study,...

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Bibliographic Details
Published in:SID International Symposium Digest of technical papers 2014-06, Vol.45 (1), p.42-45
Main Authors: Guo, Han-Wen, Wang, Hsing-Wen, Ho, Meng-Huan, Lee, Meng-Ting, Chen, Chih-Lei, Chuang, Ching-Sang, Lin, Yusin
Format: Article
Language:English
Subjects:
5-aminolevulinic acid (ALA)
Brain
gliomas
metronomic photodynamic therapy (mPDT)
Mice
organic light emitting diode (OLED)
Organic light emitting diodes
Photodynamic therapy
Pilots
Survival
Tumors
Weight reduction
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Summary:In this study, we presented a pilot study of metronomic photodynamic therapy (mPDT) by the use of organic light emitting diode (OLED) in treating treatment of brain tumor. The low cost, lightweight, and low fluence rate OLED has significant potential in the clinical mPDT applications. In this study, we treated nude mice with glioblastma by 5‐aminolevulinic acid (ALA) mediated OLED, mPDT. Afterwards, we investigated the tumor severity though bioluminescenct imaging and recorded survival days. Compared to control group (ALA treatment without illumination), PDT group mice showed increased survival days. This pilot study suggests that OLED is a useful light source for mPDT.
ISSN:0097-966X
2168-0159
DOI:10.1002/j.2168-0159.2014.tb00012.x