The potential use of diisononyl phthalate metabolites hair as biomarkers to assess long-term exposure demonstrated by a rat model

Diisononyl phthalate (DINP) is a widely used industrial plasticizer. People come into contact with this chemical by using plastic products made with it. Human health can be adversely affected by long-term DINP exposure. However, because the body rapidly excretes DINP metabolites, the use of single-p...

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Bibliographic Details
Published in:Chemosphere (Oxford) 2015-01, Vol.118, p.219-228
Main Authors: Hsu, Jen-Yi, Ho, Hsin-Hui, Liao, Pao-Chi
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Biomarkers - analysis
Biomarkers - urine
Chromatography, High Pressure Liquid
Correlation
Dose-Response Relationship, Drug
Environmental Exposure - analysis
Environmental Monitoring
Exposure
Hair
Hair - chemistry
Human
Humans
Male
Metabolites
Phthalates
Phthalic Acids - analysis
Phthalic Acids - metabolism
Phthalic Acids - urine
Plasticizers - analysis
Plasticizers - metabolism
Rats, Wistar
Tandem Mass Spectrometry
Time Factors
Tissue Distribution
Urine
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Summary:Diisononyl phthalate (DINP) is a widely used industrial plasticizer. People come into contact with this chemical by using plastic products made with it. Human health can be adversely affected by long-term DINP exposure. However, because the body rapidly excretes DINP metabolites, the use of single-point urine analysis to assess long-term exposure may produce inconsistent results in epidemiologic studies. Hair analysis has a useful place in biomonitoring, particularly in estimating long-term or historical exposure for some chemicals. Several studies have reported using hair analysis to assess the concentrations of heavy metals, drugs and organic pollutants in humans. As a biomarker, DINP metabolites were measured in rat hair in animal experiments to evaluated long-term exposure to DINP. In addition, we evaluated the correlation between the levels of DINP metabolites in hair and in urine. The levels of DINP metabolites in rat hair were significantly higher in the exposure group, relative to the control group (p
ISSN:0045-6535
1879-1298
DOI:10.1016/j.chemosphere.2014.09.025