Contribution of Fibroblasts Cultured on 3D Silica Nonwoven Fabrics to Cocultured Hepatocytes Function

It is worth investigating heterotypic cell–cell interactions by mimicking their in vivo environment. In the present study, the mechanism of functional enhancement was investigated in a hepatocyte–fibroblast coculture with respect to the contributions of soluble factors. The enhanced hepatic function...

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Bibliographic Details
Published in:Chemistry letters 2014, Vol.43 (3), p.343-345
Main Authors: Otsuka, Hidenori, Sasaki, Kohei, Okimura, Saya, Nagamura, Masako, Watanabe, Rie, Kawabe, Masaaki
Format: Article
Language:English
Subjects:
Biomedical materials
Fabrics
Fibroblasts
In vivo testing
In vivo tests
Silicon dioxide
Surgical implants
Three dimensional
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Summary:It is worth investigating heterotypic cell–cell interactions by mimicking their in vivo environment. In the present study, the mechanism of functional enhancement was investigated in a hepatocyte–fibroblast coculture with respect to the contributions of soluble factors. The enhanced hepatic functions through heterotypic interactions are effective by increasing fibroblast proliferation separately cocultured in 3D silica fabrics. The important roles of active soluble factors in heterotypic cell communications were suggested by this study using 3D proliferated tissues with satisfactory physiological morphologies in silica fabrics.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.130955