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Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid
In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of cal...
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Published in: | Materials Science & Engineering C 2014-12, Vol.45, p.64-71 |
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creator | Śmiga-Matuszowicz, Monika Janicki, Bartosz Jaszcz, Katarzyna Łukaszczyk, Jan Kaczmarek, Marcin Lesiak, Marta Sieroń, Aleksander L. Simka, Wojciech Mierzwiński, Maciej Kusz, Damian |
description | In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of calcium carbonate/carboxylic acid mixture, creating in situ porous structure during crosslinking of liquid formulations. The maximum crosslinking temperature and setting time, the cured porous materials morphology as well as the effect of their porosity on mechanical properties and hydrolytic degradation process were evaluated. It was found that the kind of carboxylic acid used in the foaming system influenced compressive strength and compressive modulus of porous scaffolds. The MTS cytotoxicity assay was carried out for OMIS using hFOB1.19 cell line. OMIS resin was found to be non-toxic in wide range of concentrations. On the ground of scanning electron microscopy (SEM) observations and energy X-ray dispersive analysis (EDX) it was found that hydroxyapatite (HA) formation at the scaffolds surfaces within short period of soaking in phosphate buffer solution occurs. After 3h immersion a compact layer of HA was observed at the surface of the samples. The obtained results suggest potential applicability of resulted new porous crosslinked polymeric materials as temporary bone void fillers.
•Isosorbide-based resin was used as a component of biodegradable scaffolds.•CAC/carboxylic acid system was proven as facile method to obtain porous scaffolds.•Porous scaffolds displayed the formation of hydroxyapatite at their surfaces. |
doi_str_mv | 10.1016/j.msec.2014.08.069 |
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•Isosorbide-based resin was used as a component of biodegradable scaffolds.•CAC/carboxylic acid system was proven as facile method to obtain porous scaffolds.•Porous scaffolds displayed the formation of hydroxyapatite at their surfaces.</description><identifier>ISSN: 0928-4931</identifier><identifier>EISSN: 1873-0191</identifier><identifier>DOI: 10.1016/j.msec.2014.08.069</identifier><identifier>PMID: 25491802</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biobased oligoesters ; Biocompatible Materials - chemical synthesis ; Biocompatible Materials - chemistry ; Biocompatible Materials - toxicity ; Carboxylic acids ; Cell Line ; Cell Survival - drug effects ; Compressive Strength ; Crosslinking ; Durapatite - chemistry ; Elastic Modulus ; Foaming ; Humans ; Hydroxyapatite ; Isosorbide ; Isosorbide - chemistry ; Microscopy, Electron, Scanning ; Orthopedic biomaterials ; Polyesters - chemistry ; Polymeric scaffolds ; Polymers ; Polymers - chemistry ; Porosity ; Resins ; Resins, Synthetic - chemistry ; Resins, Synthetic - toxicity ; Scaffolds ; Scanning electron microscopy ; Spectrometry, X-Ray Emission ; Succinic Acid - chemistry ; Temperature</subject><ispartof>Materials Science & Engineering C, 2014-12, Vol.45, p.64-71</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-61dbbffcaeff6b24c2c39070f67a3cb3f6f8d53ee084cd05776b697fcf70d4783</citedby><cites>FETCH-LOGICAL-c433t-61dbbffcaeff6b24c2c39070f67a3cb3f6f8d53ee084cd05776b697fcf70d4783</cites><orcidid>0000-0002-3894-9508</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25491802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Śmiga-Matuszowicz, Monika</creatorcontrib><creatorcontrib>Janicki, Bartosz</creatorcontrib><creatorcontrib>Jaszcz, Katarzyna</creatorcontrib><creatorcontrib>Łukaszczyk, Jan</creatorcontrib><creatorcontrib>Kaczmarek, Marcin</creatorcontrib><creatorcontrib>Lesiak, Marta</creatorcontrib><creatorcontrib>Sieroń, Aleksander L.</creatorcontrib><creatorcontrib>Simka, Wojciech</creatorcontrib><creatorcontrib>Mierzwiński, Maciej</creatorcontrib><creatorcontrib>Kusz, Damian</creatorcontrib><title>Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid</title><title>Materials Science & Engineering C</title><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><description>In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of calcium carbonate/carboxylic acid mixture, creating in situ porous structure during crosslinking of liquid formulations. The maximum crosslinking temperature and setting time, the cured porous materials morphology as well as the effect of their porosity on mechanical properties and hydrolytic degradation process were evaluated. It was found that the kind of carboxylic acid used in the foaming system influenced compressive strength and compressive modulus of porous scaffolds. The MTS cytotoxicity assay was carried out for OMIS using hFOB1.19 cell line. OMIS resin was found to be non-toxic in wide range of concentrations. On the ground of scanning electron microscopy (SEM) observations and energy X-ray dispersive analysis (EDX) it was found that hydroxyapatite (HA) formation at the scaffolds surfaces within short period of soaking in phosphate buffer solution occurs. After 3h immersion a compact layer of HA was observed at the surface of the samples. The obtained results suggest potential applicability of resulted new porous crosslinked polymeric materials as temporary bone void fillers.
•Isosorbide-based resin was used as a component of biodegradable scaffolds.•CAC/carboxylic acid system was proven as facile method to obtain porous scaffolds.•Porous scaffolds displayed the formation of hydroxyapatite at their surfaces.</description><subject>Biobased oligoesters</subject><subject>Biocompatible Materials - chemical synthesis</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - toxicity</subject><subject>Carboxylic acids</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Compressive Strength</subject><subject>Crosslinking</subject><subject>Durapatite - chemistry</subject><subject>Elastic Modulus</subject><subject>Foaming</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Isosorbide</subject><subject>Isosorbide - chemistry</subject><subject>Microscopy, Electron, Scanning</subject><subject>Orthopedic biomaterials</subject><subject>Polyesters - chemistry</subject><subject>Polymeric scaffolds</subject><subject>Polymers</subject><subject>Polymers - chemistry</subject><subject>Porosity</subject><subject>Resins</subject><subject>Resins, Synthetic - chemistry</subject><subject>Resins, Synthetic - toxicity</subject><subject>Scaffolds</subject><subject>Scanning electron microscopy</subject><subject>Spectrometry, X-Ray Emission</subject><subject>Succinic Acid - chemistry</subject><subject>Temperature</subject><issn>0928-4931</issn><issn>1873-0191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkU-r1TAQxYMovuvTL-BCsnRz66RpkxbcyMN_8NCNrkM6mUAubVMz7YX37e3lPl2Kq2GG3zkw5wjxWkGlQJl3p2piwqoG1VTQVWD6J-KgOquPoHr1VBygr7tj02t1I14wnwBMp239XNzUbdOrDuqDOH3LZxrlkLLHNZ1JLnl8IF6pSEYfYx4Dy6XQ4gsFGUue5DazX7fi1_1QiNPMcvC8L3mWiTPnMqRA0s9B8oaY5oTSYwovxbPoR6ZXj_NW_Pz08cfdl-P9989f7z7cH7HRej0aFYYhRvQUoxnqBmvUPViIxnqNg44mdqHVRNA1GKC11gymtxGjhdDYTt-Kt1ffpeRf2_6LmxIjjaOfKW_slDGwa3td_weqW4BW93ZH6yuKJTMXim4pafLlwSlwlzrcyV3qcJc6HHRur2MXvXn034aJwl_Jn_x34P0VoD2Qc6LiGBPNSCEVwtWFnP7l_xuyyZ4I</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Śmiga-Matuszowicz, Monika</creator><creator>Janicki, Bartosz</creator><creator>Jaszcz, Katarzyna</creator><creator>Łukaszczyk, Jan</creator><creator>Kaczmarek, Marcin</creator><creator>Lesiak, Marta</creator><creator>Sieroń, Aleksander L.</creator><creator>Simka, Wojciech</creator><creator>Mierzwiński, Maciej</creator><creator>Kusz, Damian</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-3894-9508</orcidid></search><sort><creationdate>20141201</creationdate><title>Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid</title><author>Śmiga-Matuszowicz, Monika ; Janicki, Bartosz ; Jaszcz, Katarzyna ; Łukaszczyk, Jan ; Kaczmarek, Marcin ; Lesiak, Marta ; Sieroń, Aleksander L. ; Simka, Wojciech ; Mierzwiński, Maciej ; Kusz, Damian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-61dbbffcaeff6b24c2c39070f67a3cb3f6f8d53ee084cd05776b697fcf70d4783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biobased oligoesters</topic><topic>Biocompatible Materials - chemical synthesis</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - toxicity</topic><topic>Carboxylic acids</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Compressive Strength</topic><topic>Crosslinking</topic><topic>Durapatite - chemistry</topic><topic>Elastic Modulus</topic><topic>Foaming</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Isosorbide</topic><topic>Isosorbide - chemistry</topic><topic>Microscopy, Electron, Scanning</topic><topic>Orthopedic biomaterials</topic><topic>Polyesters - chemistry</topic><topic>Polymeric scaffolds</topic><topic>Polymers</topic><topic>Polymers - chemistry</topic><topic>Porosity</topic><topic>Resins</topic><topic>Resins, Synthetic - chemistry</topic><topic>Resins, Synthetic - toxicity</topic><topic>Scaffolds</topic><topic>Scanning electron microscopy</topic><topic>Spectrometry, X-Ray Emission</topic><topic>Succinic Acid - chemistry</topic><topic>Temperature</topic><toplevel>online_resources</toplevel><creatorcontrib>Śmiga-Matuszowicz, Monika</creatorcontrib><creatorcontrib>Janicki, Bartosz</creatorcontrib><creatorcontrib>Jaszcz, Katarzyna</creatorcontrib><creatorcontrib>Łukaszczyk, Jan</creatorcontrib><creatorcontrib>Kaczmarek, Marcin</creatorcontrib><creatorcontrib>Lesiak, Marta</creatorcontrib><creatorcontrib>Sieroń, Aleksander L.</creatorcontrib><creatorcontrib>Simka, Wojciech</creatorcontrib><creatorcontrib>Mierzwiński, Maciej</creatorcontrib><creatorcontrib>Kusz, Damian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Materials Science & Engineering C</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Śmiga-Matuszowicz, Monika</au><au>Janicki, Bartosz</au><au>Jaszcz, Katarzyna</au><au>Łukaszczyk, Jan</au><au>Kaczmarek, Marcin</au><au>Lesiak, Marta</au><au>Sieroń, Aleksander L.</au><au>Simka, Wojciech</au><au>Mierzwiński, Maciej</au><au>Kusz, Damian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid</atitle><jtitle>Materials Science & Engineering C</jtitle><addtitle>Mater Sci Eng C Mater Biol Appl</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>45</volume><spage>64</spage><epage>71</epage><pages>64-71</pages><issn>0928-4931</issn><eissn>1873-0191</eissn><abstract>In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of calcium carbonate/carboxylic acid mixture, creating in situ porous structure during crosslinking of liquid formulations. The maximum crosslinking temperature and setting time, the cured porous materials morphology as well as the effect of their porosity on mechanical properties and hydrolytic degradation process were evaluated. It was found that the kind of carboxylic acid used in the foaming system influenced compressive strength and compressive modulus of porous scaffolds. The MTS cytotoxicity assay was carried out for OMIS using hFOB1.19 cell line. OMIS resin was found to be non-toxic in wide range of concentrations. On the ground of scanning electron microscopy (SEM) observations and energy X-ray dispersive analysis (EDX) it was found that hydroxyapatite (HA) formation at the scaffolds surfaces within short period of soaking in phosphate buffer solution occurs. After 3h immersion a compact layer of HA was observed at the surface of the samples. The obtained results suggest potential applicability of resulted new porous crosslinked polymeric materials as temporary bone void fillers.
•Isosorbide-based resin was used as a component of biodegradable scaffolds.•CAC/carboxylic acid system was proven as facile method to obtain porous scaffolds.•Porous scaffolds displayed the formation of hydroxyapatite at their surfaces.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25491802</pmid><doi>10.1016/j.msec.2014.08.069</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3894-9508</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Biobased oligoesters Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biocompatible Materials - toxicity Carboxylic acids Cell Line Cell Survival - drug effects Compressive Strength Crosslinking Durapatite - chemistry Elastic Modulus Foaming Humans Hydroxyapatite Isosorbide Isosorbide - chemistry Microscopy, Electron, Scanning Orthopedic biomaterials Polyesters - chemistry Polymeric scaffolds Polymers Polymers - chemistry Porosity Resins Resins, Synthetic - chemistry Resins, Synthetic - toxicity Scaffolds Scanning electron microscopy Spectrometry, X-Ray Emission Succinic Acid - chemistry Temperature |
title | Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid |
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