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Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid

In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of cal...

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Published in:Materials Science & Engineering C 2014-12, Vol.45, p.64-71
Main Authors: Śmiga-Matuszowicz, Monika, Janicki, Bartosz, Jaszcz, Katarzyna, Łukaszczyk, Jan, Kaczmarek, Marcin, Lesiak, Marta, Sieroń, Aleksander L., Simka, Wojciech, Mierzwiński, Maciej, Kusz, Damian
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cited_by cdi_FETCH-LOGICAL-c433t-61dbbffcaeff6b24c2c39070f67a3cb3f6f8d53ee084cd05776b697fcf70d4783
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container_title Materials Science & Engineering C
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creator Śmiga-Matuszowicz, Monika
Janicki, Bartosz
Jaszcz, Katarzyna
Łukaszczyk, Jan
Kaczmarek, Marcin
Lesiak, Marta
Sieroń, Aleksander L.
Simka, Wojciech
Mierzwiński, Maciej
Kusz, Damian
description In this study new biodegradable materials obtained by crosslinking poly(3-allyloxy-1,2-propylene succinate) (PSAGE) with oligo(isosorbide maleate) (OMIS) and small amount of methyl methacrylate were investigated. The porous scaffolds were obtained in the presence of a foaming system consisted of calcium carbonate/carboxylic acid mixture, creating in situ porous structure during crosslinking of liquid formulations. The maximum crosslinking temperature and setting time, the cured porous materials morphology as well as the effect of their porosity on mechanical properties and hydrolytic degradation process were evaluated. It was found that the kind of carboxylic acid used in the foaming system influenced compressive strength and compressive modulus of porous scaffolds. The MTS cytotoxicity assay was carried out for OMIS using hFOB1.19 cell line. OMIS resin was found to be non-toxic in wide range of concentrations. On the ground of scanning electron microscopy (SEM) observations and energy X-ray dispersive analysis (EDX) it was found that hydroxyapatite (HA) formation at the scaffolds surfaces within short period of soaking in phosphate buffer solution occurs. After 3h immersion a compact layer of HA was observed at the surface of the samples. The obtained results suggest potential applicability of resulted new porous crosslinked polymeric materials as temporary bone void fillers. •Isosorbide-based resin was used as a component of biodegradable scaffolds.•CAC/carboxylic acid system was proven as facile method to obtain porous scaffolds.•Porous scaffolds displayed the formation of hydroxyapatite at their surfaces.
doi_str_mv 10.1016/j.msec.2014.08.069
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ispartof Materials Science & Engineering C, 2014-12, Vol.45, p.64-71
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1873-0191
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source Elsevier
subjects Biobased oligoesters
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biocompatible Materials - toxicity
Carboxylic acids
Cell Line
Cell Survival - drug effects
Compressive Strength
Crosslinking
Durapatite - chemistry
Elastic Modulus
Foaming
Humans
Hydroxyapatite
Isosorbide
Isosorbide - chemistry
Microscopy, Electron, Scanning
Orthopedic biomaterials
Polyesters - chemistry
Polymeric scaffolds
Polymers
Polymers - chemistry
Porosity
Resins
Resins, Synthetic - chemistry
Resins, Synthetic - toxicity
Scaffolds
Scanning electron microscopy
Spectrometry, X-Ray Emission
Succinic Acid - chemistry
Temperature
title Novel bioactive polyester scaffolds prepared from unsaturated resins based on isosorbide and succinic acid
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