Integrated solid-state nanopore devices for third generation DNA sequencing

Third generation DNA sequencing relies on monitoring the ionic current blockage during the DNA molecule＇s threading through a nanoscale pore. It is still really tough to attain the single base discrimination on a DNA strand by merely analyzing the ionic current due to speedy DNA translocation and lo...

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Bibliographic Details
Published in:Science China. Technological sciences 2014, Vol.57 (10), p.1925-1935
Main Authors: Wu, GenSheng, Zhang, Yin, Si, Wei, Sha, JingJie, Liu, Lei, Chen, YunFei
Format: Article
Language:English
Subjects:
Blockage
China
Deoxyribonucleic acid
DNA分子
DNA测序
Electric potential
Engineering
Gene sequencing
Monitoring
Nanostructure
Review
Spatial resolution
Voltage
固态
第三代
纳米孔
设备
集成
高空间分辨率
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Summary:Third generation DNA sequencing relies on monitoring the ionic current blockage during the DNA molecule＇s threading through a nanoscale pore. It is still really tough to attain the single base discrimination on a DNA strand by merely analyzing the ionic current due to speedy DNA translocation and low spatial resolution. More integrated configurations are pursued to present versatile comparative dissimilarities of the four bases by enhancing the spatial resolution within a DNA molecule translocation event, such as transverse tunneling current, local potential change, and capacitance oriented voltage resonance. In this mini review, the insight is provided into the status quo on several functionalized techniques and methodologies for DNA sequencing and furthermore concluding remark and outlook are presented.
ISSN:1674-7321
1869-1900
DOI:10.1007/s11431-014-5644-8