Novel silicone hydrogel based on PDMS and PEGMA for contact lens application

A silicone-based hydrogel was synthesized from poly(dimethylsiloxane) dialkanol (PDMS), isophorone diisocyanate (IPDI), 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) methacrylate (PEGMA). The hydrophilicity of the resulting block copolymer was adjustable by manipulating the ratio of P...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-11, Vol.123, p.986-994
Main Authors: Lin, Chien-Hong, Yeh, Yi-Hsing, Lin, Wen-Ching, Yang, Ming-Chien
Format: Article
Language:English
Subjects:
Cell Line
Cell Survival - drug effects
Contact
Dimethylpolysiloxanes - chemistry
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate - adverse effects
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogels
Hydrophilicity
Lenses
Methacrylates - chemistry
Permeability
Polyethylene Glycols - chemistry
Protein adsorption
Silicone resins
Silicones
Silicones - chemistry
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Summary:A silicone-based hydrogel was synthesized from poly(dimethylsiloxane) dialkanol (PDMS), isophorone diisocyanate (IPDI), 2-hydroxyethyl methacrylate (HEMA) and poly(ethylene glycol) methacrylate (PEGMA). The hydrophilicity of the resulting block copolymer was adjustable by manipulating the ratio of PDMS and PEGMA. The results showed that higher PEGMA content led to a lower water contact angle, higher water content, lower elastic modulus and higher glucose permeability. At a PEGMA content of 20%, the protein adsorption decreased to 23% and 18% for lysozyme and human serum albumin (HSA), respectively, of those of the control (PDMS-PU). This indicated that the PDMS-PU-PEGMA hydrogels exhibited an ability to resist protein adsorption. The oxygen permeability (Dk) was 92 barrers for the hydrogel with 20% PEGMA. Furthermore, these hydrogels were non-cytotoxic according to an in vitro L929 fibroblast assay. Overall, the results demonstrated that the PDMS-PU-PEGMA hydrogels exhibited not only relatively high oxygen permeability and relative optical transparency, but also hydrophilicity and anti-protein adsorption; therefore, they would be applicable as a contact lens material. Furthermore, this study demonstrated a new approach to controlling the performance of silicone hydrogels.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2014.10.053