A Multitheragnostic Nanobubble System to Induce Blood-Brain Barrier Disruption with Magnetically Guided Focused Ultrasound

A novel magnetically guidable nanobubble is designed for disrupting the blood–brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic‐nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2015-01, Vol.27 (4), p.655-661
Main Authors: Huang, Hsin-Yang, Liu, Hao-Li, Hsu, Po-Hung, Chiang, Chih-Sheng, Tsai, Chih-Hung, Chi, Huei-Shang, Chen, San-Yuan, Chen, You-Yin
Format: Article
Language:English
Subjects:
Animals
Biomedical materials
Blood-brain barrier
Blood-Brain Barrier - metabolism
brain-blood barrier
Contrast Media - chemistry
Disruption
Ferric Compounds - chemistry
focused ultrasound
In vivo testing
In vivo tests
magnetic guidance
Magnetic Phenomena
Magnetic resonance imaging
Mice
nanobubbles
Nanoparticles - chemistry
Nanoparticles - therapeutic use
Nanostructure
Silicon Dioxide - chemistry
Ultrasonics
Ultrasound
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Summary:A novel magnetically guidable nanobubble is designed for disrupting the blood–brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic‐nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)‐induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual‐modality contrast‐agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201403889