Rapid electronic prediction of gene expression regulation in bacterial cells

A cytomorphic circuit that can mimic gene expression regulation mechanisms is presented. It is shown that this circuit can efficiently predict the cellular response of the bacterium Escherichia coli in real time. The simulation outputs of the circuit are compared with biological experimental results...

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Bibliographic Details
Published in:Electronics letters 2014-10, Vol.50 (22), p.1566-1568
Main Authors: Alam, S, Lai, E.M-K, Young, J, Hasan, S.M.R
Format: Article
Language:English
Subjects:
Bacteria
bacterial cells
Bioinspired technology
Cellular
cellular biophysics
cellular malfunctioning
cellular response
Circuits
cytomorphic circuit
Electronics
Escherichia coli
Escherichia coli bacterium
Gene expression
gene expression regulation
genetics
microorganisms
microseconds
rapid electronic prediction
Real time
Similarity
Simulation
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Summary:A cytomorphic circuit that can mimic gene expression regulation mechanisms is presented. It is shown that this circuit can efficiently predict the cellular response of the bacterium Escherichia coli in real time. The simulation outputs of the circuit are compared with biological experimental results. The significant similarity between these results shows that the circuit can be used to predict cellular malfunctioning within microseconds.
ISSN:0013-5194
1350-911X
1350-911X
DOI:10.1049/el.2014.2144