Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease

Abstract Objectives Vitamin C is a major antioxidant and also is known as a neuromodulator in dopaminergic neurons. The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD). Methods Sixty-two individual...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-02, Vol.31 (2), p.406-408
Main Authors: Ide, Kazuki, M.Sc, Yamada, Hiroshi, M.D., Ph.D, Umegaki, Keizo, Ph.D, Mizuno, Katsuki, B.A, Kawakami, Nobuko, M.D, Hagiwara, Yuka, M.D, Matsumoto, Mizuki, M.D, Yoshida, Hidefumi, M.D, Kim, Kang, M.D, Shiosaki, Emi, B.A, Yokochi, Tsunehiro, B.A, Harada, Kiyoshi, M.D., Ph.D
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antioxidants
Ascorbic Acid - administration & dosage
Ascorbic Acid - blood
Biomarkers
Biomarkers - blood
Body mass index
Clinical assessment
Disease Progression
Female
Gastroenterology and Hepatology
Humans
Logistic Models
Lymphocytes
Lymphocytes - chemistry
Male
Middle Aged
Multivariate Analysis
Oxidative stress
Oxidative Stress - drug effects
Parkinson Disease - blood
Parkinson's disease
Vitamin C
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Summary:Abstract Objectives Vitamin C is a major antioxidant and also is known as a neuromodulator in dopaminergic neurons. The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD). Methods Sixty-two individuals with PD (age 71 ± 8.8 y [mean ± SD]) being treated at Shizuoka General Hospital from December 2007 to August 2013 were consecutively recruited. PD severity was classified using the Hoehn-Yahr scale for staging PD. Fasting blood samples were collected, and plasma and lymphocyte vitamin C levels were measured. The association between PD severity and vitamin C levels was estimated by ordinal logistic regression with confounding variables. Results The distribution of Hoehn-Yahr stages in patients was as follows: stage I, 7; II, 28; III, 16; and IV, 11. Lymphocyte vitamin C levels in patients with severe PD were significantly lower (odds ratio [OR], 0.87; 95% confidence interval [CI], 0.80–0.97; P  
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2014.08.001