Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease

Abstract Objectives Vitamin C is a major antioxidant and also is known as a neuromodulator in dopaminergic neurons. The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD). Methods Sixty-two individual...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-02, Vol.31 (2), p.406-408
Main Authors: Ide, Kazuki, M.Sc, Yamada, Hiroshi, M.D., Ph.D, Umegaki, Keizo, Ph.D, Mizuno, Katsuki, B.A, Kawakami, Nobuko, M.D, Hagiwara, Yuka, M.D, Matsumoto, Mizuki, M.D, Yoshida, Hidefumi, M.D, Kim, Kang, M.D, Shiosaki, Emi, B.A, Yokochi, Tsunehiro, B.A, Harada, Kiyoshi, M.D., Ph.D
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antioxidants
Ascorbic Acid - administration & dosage
Ascorbic Acid - blood
Biomarkers
Biomarkers - blood
Body mass index
Clinical assessment
Disease Progression
Female
Gastroenterology and Hepatology
Humans
Logistic Models
Lymphocytes
Lymphocytes - chemistry
Male
Middle Aged
Multivariate Analysis
Oxidative stress
Oxidative Stress - drug effects
Parkinson Disease - blood
Parkinson's disease
Vitamin C
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cited_by cdi_FETCH-LOGICAL-c469t-609fb819263885c659aa482012a77dcf0431a44e435e37fd3126bb2df32d45bf3
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container_start_page 406
container_title Nutrition (Burbank, Los Angeles County, Calif.)
container_volume 31
creator Ide, Kazuki, M.Sc
Yamada, Hiroshi, M.D., Ph.D
Umegaki, Keizo, Ph.D
Mizuno, Katsuki, B.A
Kawakami, Nobuko, M.D
Hagiwara, Yuka, M.D
Matsumoto, Mizuki, M.D
Yoshida, Hidefumi, M.D
Kim, Kang, M.D
Shiosaki, Emi, B.A
Yokochi, Tsunehiro, B.A
Harada, Kiyoshi, M.D., Ph.D
description Abstract Objectives Vitamin C is a major antioxidant and also is known as a neuromodulator in dopaminergic neurons. The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD). Methods Sixty-two individuals with PD (age 71 ± 8.8 y [mean ± SD]) being treated at Shizuoka General Hospital from December 2007 to August 2013 were consecutively recruited. PD severity was classified using the Hoehn-Yahr scale for staging PD. Fasting blood samples were collected, and plasma and lymphocyte vitamin C levels were measured. The association between PD severity and vitamin C levels was estimated by ordinal logistic regression with confounding variables. Results The distribution of Hoehn-Yahr stages in patients was as follows: stage I, 7; II, 28; III, 16; and IV, 11. Lymphocyte vitamin C levels in patients with severe PD were significantly lower (odds ratio [OR], 0.87; 95% confidence interval [CI], 0.80–0.97; P  
doi_str_mv 10.1016/j.nut.2014.08.001
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The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD). Methods Sixty-two individuals with PD (age 71 ± 8.8 y [mean ± SD]) being treated at Shizuoka General Hospital from December 2007 to August 2013 were consecutively recruited. PD severity was classified using the Hoehn-Yahr scale for staging PD. Fasting blood samples were collected, and plasma and lymphocyte vitamin C levels were measured. The association between PD severity and vitamin C levels was estimated by ordinal logistic regression with confounding variables. Results The distribution of Hoehn-Yahr stages in patients was as follows: stage I, 7; II, 28; III, 16; and IV, 11. Lymphocyte vitamin C levels in patients with severe PD were significantly lower (odds ratio [OR], 0.87; 95% confidence interval [CI], 0.80–0.97; P  &lt; 0.01) compared with those at less severe stages. Plasma vitamin C levels also tended to be lower in patients with severe PD; however, this was not significant (OR, 0.98; 95% CI, 0.96–1.00; P  = 0.09). Conclusions Our findings suggest that lymphocyte vitamin C levels in the peripheral blood may be a potentially useful biomarker for the progression of PD.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2014.08.001</identifier><identifier>PMID: 25592020</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Antioxidants ; Ascorbic Acid - administration &amp; dosage ; Ascorbic Acid - blood ; Biomarkers ; Biomarkers - blood ; Body mass index ; Clinical assessment ; Disease Progression ; Female ; Gastroenterology and Hepatology ; Humans ; Logistic Models ; Lymphocytes ; Lymphocytes - chemistry ; Male ; Middle Aged ; Multivariate Analysis ; Oxidative stress ; Oxidative Stress - drug effects ; Parkinson Disease - blood ; Parkinson's disease ; Vitamin C</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2015-02, Vol.31 (2), p.406-408</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-609fb819263885c659aa482012a77dcf0431a44e435e37fd3126bb2df32d45bf3</citedby><cites>FETCH-LOGICAL-c469t-609fb819263885c659aa482012a77dcf0431a44e435e37fd3126bb2df32d45bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25592020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ide, Kazuki, M.Sc</creatorcontrib><creatorcontrib>Yamada, Hiroshi, M.D., Ph.D</creatorcontrib><creatorcontrib>Umegaki, Keizo, Ph.D</creatorcontrib><creatorcontrib>Mizuno, Katsuki, B.A</creatorcontrib><creatorcontrib>Kawakami, Nobuko, M.D</creatorcontrib><creatorcontrib>Hagiwara, Yuka, M.D</creatorcontrib><creatorcontrib>Matsumoto, Mizuki, M.D</creatorcontrib><creatorcontrib>Yoshida, Hidefumi, M.D</creatorcontrib><creatorcontrib>Kim, Kang, M.D</creatorcontrib><creatorcontrib>Shiosaki, Emi, B.A</creatorcontrib><creatorcontrib>Yokochi, Tsunehiro, B.A</creatorcontrib><creatorcontrib>Harada, Kiyoshi, M.D., Ph.D</creatorcontrib><title>Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objectives Vitamin C is a major antioxidant and also is known as a neuromodulator in dopaminergic neurons. The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD). Methods Sixty-two individuals with PD (age 71 ± 8.8 y [mean ± SD]) being treated at Shizuoka General Hospital from December 2007 to August 2013 were consecutively recruited. PD severity was classified using the Hoehn-Yahr scale for staging PD. Fasting blood samples were collected, and plasma and lymphocyte vitamin C levels were measured. The association between PD severity and vitamin C levels was estimated by ordinal logistic regression with confounding variables. Results The distribution of Hoehn-Yahr stages in patients was as follows: stage I, 7; II, 28; III, 16; and IV, 11. Lymphocyte vitamin C levels in patients with severe PD were significantly lower (odds ratio [OR], 0.87; 95% confidence interval [CI], 0.80–0.97; P  &lt; 0.01) compared with those at less severe stages. Plasma vitamin C levels also tended to be lower in patients with severe PD; however, this was not significant (OR, 0.98; 95% CI, 0.96–1.00; P  = 0.09). Conclusions Our findings suggest that lymphocyte vitamin C levels in the peripheral blood may be a potentially useful biomarker for the progression of PD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antioxidants</subject><subject>Ascorbic Acid - administration &amp; dosage</subject><subject>Ascorbic Acid - blood</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Body mass index</subject><subject>Clinical assessment</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Lymphocytes</subject><subject>Lymphocytes - chemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Parkinson Disease - blood</subject><subject>Parkinson's disease</subject><subject>Vitamin C</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkk2r1DAUhoMo3rlXf4AbCbjQTevJR9MGQZDBq8KAgrpwFdL0VDO3bcakHZh_b8pcFe5CXGWR533JyXMIecKgZMDUy305LXPJgckSmhKA3SMb1tSiYFzK-2QDjdaFBqgvyGVKe8iEVvohueBVpTlw2JBvu9N4-BHcaUZ69LMd_US3dMAjDonaRA9hxmn2dqCtD6ONNxhpHyI9xPA9Yko-TDT09FO-8VMK0_NEO5_QJnxEHvR2SPj49rwiX6_fftm-L3Yf333YvtkVTio9Fwp03zZMcyWapnKq0tbKJs_EbV13rgcpmJUSpahQ1H0nGFdty7te8E5WbS-uyItzb37SzwXTbEafHA6DnTAsyTClQDSV4Po_0IqLhivGMvrsDroPS5zyIJmSsq5y61rIzpSLIaWIvTlEn3_pZBiYVZHZm6zIrIoMNCYLyJmnt81LO2L3J_HbSQZenYGsAI8eo0nO4-Sw8xHdbLrg_1n_-k7aDX7yzg43eML0dwqTuAHzed2RdUWYBBAalPgF1v20_w</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Ide, Kazuki, M.Sc</creator><creator>Yamada, Hiroshi, M.D., Ph.D</creator><creator>Umegaki, Keizo, Ph.D</creator><creator>Mizuno, Katsuki, B.A</creator><creator>Kawakami, Nobuko, M.D</creator><creator>Hagiwara, Yuka, M.D</creator><creator>Matsumoto, Mizuki, M.D</creator><creator>Yoshida, Hidefumi, M.D</creator><creator>Kim, Kang, M.D</creator><creator>Shiosaki, Emi, B.A</creator><creator>Yokochi, Tsunehiro, B.A</creator><creator>Harada, Kiyoshi, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20150201</creationdate><title>Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease</title><author>Ide, Kazuki, M.Sc ; 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The aim of this study was to investigate the association between lymphocyte and plasma vitamin C levels in various stages of Parkinson's disease (PD). Methods Sixty-two individuals with PD (age 71 ± 8.8 y [mean ± SD]) being treated at Shizuoka General Hospital from December 2007 to August 2013 were consecutively recruited. PD severity was classified using the Hoehn-Yahr scale for staging PD. Fasting blood samples were collected, and plasma and lymphocyte vitamin C levels were measured. The association between PD severity and vitamin C levels was estimated by ordinal logistic regression with confounding variables. Results The distribution of Hoehn-Yahr stages in patients was as follows: stage I, 7; II, 28; III, 16; and IV, 11. Lymphocyte vitamin C levels in patients with severe PD were significantly lower (odds ratio [OR], 0.87; 95% confidence interval [CI], 0.80–0.97; P  &lt; 0.01) compared with those at less severe stages. Plasma vitamin C levels also tended to be lower in patients with severe PD; however, this was not significant (OR, 0.98; 95% CI, 0.96–1.00; P  = 0.09). Conclusions Our findings suggest that lymphocyte vitamin C levels in the peripheral blood may be a potentially useful biomarker for the progression of PD.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25592020</pmid><doi>10.1016/j.nut.2014.08.001</doi><tpages>3</tpages></addata></record>
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ispartof Nutrition (Burbank, Los Angeles County, Calif.), 2015-02, Vol.31 (2), p.406-408
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subjects Aged
Aged, 80 and over
Antioxidants
Ascorbic Acid - administration & dosage
Ascorbic Acid - blood
Biomarkers
Biomarkers - blood
Body mass index
Clinical assessment
Disease Progression
Female
Gastroenterology and Hepatology
Humans
Logistic Models
Lymphocytes
Lymphocytes - chemistry
Male
Middle Aged
Multivariate Analysis
Oxidative stress
Oxidative Stress - drug effects
Parkinson Disease - blood
Parkinson's disease
Vitamin C
title Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease
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