The effect of chronic intermittent ethanol exposure on spatial memory in adolescent rats: The dissociation of metabolic and cognitive tolerances

Abstract Using a rapid chronic intermittent ethanol (CIE) vapor exposure paradigm, we demonstrate the dissociability of metabolic tolerance from cognitive tolerance in adolescent rats. Adolescent rats were trained to spatially navigate in the Morris Water Maze and then exposed to CIE vapor or air 16...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 2012-05, Vol.1453, p.34-39
Main Authors: Van Skike, Candice E, Novier, Adelle, Diaz-Granados, Jaime L, Matthews, Douglas B
Format: Article
Language:English
Subjects:
Addictive behaviors
adolescence
Adolescent
adolescents
Adult and adolescent clinical studies
Alcoholism
Alcoholism and acute alcohol poisoning
Animals
Binge alcohol
Biological and medical sciences
blood
brain
Chronic intermittent ethanol
cognition
Cognition - drug effects
Drug Tolerance
ethanol
Ethanol - administration & dosage
Ethanol - blood
Hippocampus
Male
Maze Learning - drug effects
Medical sciences
memory
Memory - drug effects
Morris Water Maze
Neurology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Rats
Rats, Sprague-Dawley
Spatial memory
Toxicology
vapors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Using a rapid chronic intermittent ethanol (CIE) vapor exposure paradigm, we demonstrate the dissociability of metabolic tolerance from cognitive tolerance in adolescent rats. Adolescent rats were trained to spatially navigate in the Morris Water Maze and then exposed to CIE vapor or air 16 h a day for 4 days. After a final 28 h withdrawal, all rats received a saline or ethanol challenge, followed by a test of spatial memory 30 min after administration. Results indicate that CIE vapor exposure did not significantly impair adolescent spatial memory. Although CIE-exposed rats developed metabolic tolerance to a subsequent ethanol administration, CIE exposure did not alter dose-dependent ethanol-induced spatial memory impairments. These data indicate that metabolic ethanol tolerance can be distinguished from cognitive ethanol tolerance during adolescence and suggest that blood alcohol levels alone do not fully explain ethanol-induced spatial memory impairments.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2012.03.006