Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats

[Display omitted] In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tar...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2015-02, Vol.25 (3), p.673-679
Main Authors: Lu, Yiqin, He, Bo, Zhang, Xiaochao, Yang, Renhua, Li, Shude, Song, Bo, Zhang, Yue, Yun, Yu, Yan, Hongli, Chen, Peng, Shen, Zhiqiang
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Animals
Biomechanics
Bone Density - drug effects
Bone turnover
Calcitonin - blood
Calcium - blood
Disease Models, Animal
Estradiol - blood
Female
Femur - drug effects
Femur - metabolism
Femur - pathology
Geraniin
Glucosides - chemistry
Glucosides - pharmacology
Glucosides - therapeutic use
Hydrolyzable Tannins - chemistry
Hydrolyzable Tannins - pharmacology
Hydrolyzable Tannins - therapeutic use
Osteoporosis - drug therapy
Osteoporosis - etiology
Ovariectomy
Ovariectomy-induced osteoporosis
Rats
Rats, Wistar
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation. These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2014.11.081