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Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats
[Display omitted] In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tar...
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| Published in: | Bioorganic & medicinal chemistry letters 2015-02, Vol.25 (3), p.673-679 |
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| Main Authors: | , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c525t-fbc0c048b5edd39977d14d4ab9919bf0a905a23a48be85623bf78f2d1d592bd53 |
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| container_end_page | 679 |
| container_issue | 3 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Lu, Yiqin He, Bo Zhang, Xiaochao Yang, Renhua Li, Shude Song, Bo Zhang, Yue Yun, Yu Yan, Hongli Chen, Peng Shen, Zhiqiang |
| description | [Display omitted]
In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation. These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis. |
| doi_str_mv | 10.1016/j.bmcl.2014.11.081 |
| format | article |
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In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation. These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis.</description><identifier>ISSN: 0960-894X</identifier><identifier>EISSN: 1464-3405</identifier><identifier>DOI: 10.1016/j.bmcl.2014.11.081</identifier><identifier>PMID: 25532904</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alkaline Phosphatase - blood ; Animals ; Biomechanics ; Bone Density - drug effects ; Bone turnover ; Calcitonin - blood ; Calcium - blood ; Disease Models, Animal ; Estradiol - blood ; Female ; Femur - drug effects ; Femur - metabolism ; Femur - pathology ; Geraniin ; Glucosides - chemistry ; Glucosides - pharmacology ; Glucosides - therapeutic use ; Hydrolyzable Tannins - chemistry ; Hydrolyzable Tannins - pharmacology ; Hydrolyzable Tannins - therapeutic use ; Osteoporosis - drug therapy ; Osteoporosis - etiology ; Ovariectomy ; Ovariectomy-induced osteoporosis ; Rats ; Rats, Wistar</subject><ispartof>Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (3), p.673-679</ispartof><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-fbc0c048b5edd39977d14d4ab9919bf0a905a23a48be85623bf78f2d1d592bd53</citedby><cites>FETCH-LOGICAL-c525t-fbc0c048b5edd39977d14d4ab9919bf0a905a23a48be85623bf78f2d1d592bd53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25532904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Yiqin</creatorcontrib><creatorcontrib>He, Bo</creatorcontrib><creatorcontrib>Zhang, Xiaochao</creatorcontrib><creatorcontrib>Yang, Renhua</creatorcontrib><creatorcontrib>Li, Shude</creatorcontrib><creatorcontrib>Song, Bo</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Yun, Yu</creatorcontrib><creatorcontrib>Yan, Hongli</creatorcontrib><creatorcontrib>Chen, Peng</creatorcontrib><creatorcontrib>Shen, Zhiqiang</creatorcontrib><title>Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats</title><title>Bioorganic & medicinal chemistry letters</title><addtitle>Bioorg Med Chem Lett</addtitle><description>[Display omitted]
In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation. These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis.</description><subject>Alkaline Phosphatase - blood</subject><subject>Animals</subject><subject>Biomechanics</subject><subject>Bone Density - drug effects</subject><subject>Bone turnover</subject><subject>Calcitonin - blood</subject><subject>Calcium - blood</subject><subject>Disease Models, Animal</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Femur - drug effects</subject><subject>Femur - metabolism</subject><subject>Femur - pathology</subject><subject>Geraniin</subject><subject>Glucosides - chemistry</subject><subject>Glucosides - pharmacology</subject><subject>Glucosides - therapeutic use</subject><subject>Hydrolyzable Tannins - chemistry</subject><subject>Hydrolyzable Tannins - pharmacology</subject><subject>Hydrolyzable Tannins - therapeutic use</subject><subject>Osteoporosis - drug therapy</subject><subject>Osteoporosis - etiology</subject><subject>Ovariectomy</subject><subject>Ovariectomy-induced osteoporosis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqNkMlKBDEURYMo2g4_4EJq6abKl1RSXQE3Ik7QoAsFdyHDi6SpQZPqBv_eNK0uxVVCcu7lvUPIKYWKAm0ulpXpbVcxoLyitIKW7pAZ5Q0vaw5il8xANlC2kr8ekMOUlpBB4HyfHDAhaiaBz8jTY5pwfI_jhHYKayzQ-3wrRl-8YdRDCEOh33QYUn5b6xjy59h_lmFwK4uuMOOARTemVGQw6ikdkz2vu4Qn3-cRebm9eb6-LxePdw_XV4vSCiam0hsLFnhrBDpXSzmfO8od10ZKKo0HLUFoVutMYCsaVhs_bz1z1AnJjBP1ETnf9ubZP1aYJtWHZLHr9IDjKinaNFBLYM1_UME4la3YoGyL2ph3iujVewy9jp-KgtpIV0u1ka420hWlKkvPobPv_pXp0f1Gfixn4HILYBayDhhVsgGH7C_E7FO5MfzV_wWuW5Nf</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Lu, Yiqin</creator><creator>He, Bo</creator><creator>Zhang, Xiaochao</creator><creator>Yang, Renhua</creator><creator>Li, Shude</creator><creator>Song, Bo</creator><creator>Zhang, Yue</creator><creator>Yun, Yu</creator><creator>Yan, Hongli</creator><creator>Chen, Peng</creator><creator>Shen, Zhiqiang</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20150201</creationdate><title>Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats</title><author>Lu, Yiqin ; 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In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. The analysis of biochemical parameters showed that geraniin could significantly increase serum calcium, estradiol and calcitonin levels, and decrease serum ALP, tartrate-resistant acid phosphatase, serum crosslinked C-terminal telopeptide of type I collagen, and urinary deoxypyridinoline/creatinine ratio levels, respectively. Geraniin was also found to prevent OVX-induced bone loss in bone mineral density and bone mineral content, to elevate femur weight and bone calcium content, and to enhance the bone mechanical properties as compared with OVX group. In addition, geraniin was demonstrated to improve the histomorphological parameters of OVX-induced bone loss, including bone trabecular number, thickness, and separation. These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25532904</pmid><doi>10.1016/j.bmcl.2014.11.081</doi><tpages>7</tpages></addata></record> |
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| subjects | Alkaline Phosphatase - blood Animals Biomechanics Bone Density - drug effects Bone turnover Calcitonin - blood Calcium - blood Disease Models, Animal Estradiol - blood Female Femur - drug effects Femur - metabolism Femur - pathology Geraniin Glucosides - chemistry Glucosides - pharmacology Glucosides - therapeutic use Hydrolyzable Tannins - chemistry Hydrolyzable Tannins - pharmacology Hydrolyzable Tannins - therapeutic use Osteoporosis - drug therapy Osteoporosis - etiology Ovariectomy Ovariectomy-induced osteoporosis Rats Rats, Wistar |
| title | Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats |
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