Eosinophil Degranulation and the Release of Eosinophil Peroxidase Contributes to the Induced Inflammation Occurring in Mice Following Skin Exposure to TMA

Results EPX knockout mice displayed decreases the skin inflammation (i.e., decreases in eosinophil accumulation, mast cell activation, and skin thickness) that were similar to the reduced inflammatory events (relative to wild type controls) occurring in eosinophil deficient PHIL mice.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB265-AB265
Main Authors: Luo, Huijun, PhD, Protheroe, Cheryl A, Blum, Emily D., PhD, Fryer, Allison, PhD, Lee, Nancy A., PhD, Jacoby, David B., MD, Lee, James J., PhD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Gene expression
Rodents
Online Access:Get full text
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Description
Summary:Results EPX knockout mice displayed decreases the skin inflammation (i.e., decreases in eosinophil accumulation, mast cell activation, and skin thickness) that were similar to the reduced inflammatory events (relative to wild type controls) occurring in eosinophil deficient PHIL mice.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1807