Performance assessment of the BD MAX Cdiff assay in comparison to Xpert C. difficile assay in a setting with very low prevalence of toxigenic Clostridium difficile PCR ribotype 027

In a clinical setting with low prevalence of ‘epidemic’ PCR ribotype 027, the BD MAX Cdiff assay was found to be a suitable alternative to the Xpert C. difficile assay for the detection of toxigenic Clostridium difficile in samples which are reflex PCR tested after obtaining a discrepant immunoassay...

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Bibliographic Details
Published in:Anaerobe 2014-12, Vol.30, p.156-158
Main Authors: Chiang, Donald, Ng, Sally, La, My-Van, Jureen, Roland, Lin, Raymond T.P., Teo, Jeanette W.P.
Format: Article
Language:English
Subjects:
Bacteriological Techniques - methods
Clostridium
Clostridium difficile
Clostridium difficile - classification
Clostridium difficile - genetics
Clostridium difficile - isolation & purification
Clostridium Infections - diagnosis
Clostridium Infections - epidemiology
Clostridium Infections - microbiology
Humans
Molecular Diagnostic Techniques - methods
Nosocomial infection
Polymerase Chain Reaction
Prevalence
Real-time PCR
Ribotyping
Sensitivity and Specificity
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Summary:In a clinical setting with low prevalence of ‘epidemic’ PCR ribotype 027, the BD MAX Cdiff assay was found to be a suitable alternative to the Xpert C. difficile assay for the detection of toxigenic Clostridium difficile in samples which are reflex PCR tested after obtaining a discrepant immunoassay result. There was no significant difference between the sensitivities and specificities of both commercial molecular assays.
ISSN:1075-9964
1095-8274
DOI:10.1016/j.anaerobe.2014.09.021