Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain

ABSTRACT Lactate is shuttled between organs, as demonstrated in the Cori cycle. Although the brain releases lactate at rest, during physical exercise there is a cerebral uptake of lactate. Here, we evaluated the cerebral lactate uptake and release in hypoxia, during exercise and when the two interve...

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Published in:The FASEB journal 2012-07, Vol.26 (7), p.3012-3020
Main Authors: Overgaard, Morten, Rasmussen, Peter, Bohm, Aske M., Seifert, Thomas, Brassard, Patrice, Zaar, Morten, Homann, Pernille, Evans, Kevin A., Nielsen, Henning B., Secher, Niels H.
Format: Article
Language:English
Subjects:
Adult
Biological Transport, Active
Blood Flow Velocity
Brain - blood supply
Brain - metabolism
cerebral blood flow
cerebral metabolism
Cerebrovascular Circulation
Energy Metabolism
Exercise - physiology
Female
Humans
Hypoxia - blood
Hypoxia - metabolism
Lactic Acid - blood
Lactic Acid - metabolism
Male
Mitochondria - metabolism
Oxidation-Reduction
tracers
Young Adult
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Summary:ABSTRACT Lactate is shuttled between organs, as demonstrated in the Cori cycle. Although the brain releases lactate at rest, during physical exercise there is a cerebral uptake of lactate. Here, we evaluated the cerebral lactate uptake and release in hypoxia, during exercise and when the two interventions were combined. We measured cerebral lactate turnover via a tracer dilution method ([1‐13C]lactate), using arterial to right internal jugular venous differences in 9 healthy individuals (5 males and 4 females), at rest and during 30 min of submaximal exercise in normoxia and hypoxia (Fio2 10%, arterial oxygen saturation 72±10%, mean±sd). Whole‐body lactate turnover increased 3.5‐fold and 9‐fold at two workloads in normoxia and 18‐fold during exercise in hypoxia. Although middle cerebral artery mean flow velocity increased during exercise in hypoxia, calculated cerebral mitochondrial oxygen tension decreased by 13 mmHg (P
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.11-191999