Overexpression of microRNA biogenesis machinery: Drosha, DGCR8 and Dicer in multiple sclerosis patients

Abstract We aimed to evaluate the expression of the major components of microRNA biogenesis machinery including Drosha, Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) in multiple sclerosis (MS) patients. The expression levels of these components in relapsing remitting multiple sclerosis...

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Bibliographic Details
Published in:Journal of clinical neuroscience 2015-01, Vol.22 (1), p.200-203
Main Authors: Jafari, Naser, Shaghaghi, Hassan, Mahmoodi, Davood, Shirzad, Zohreh, Alibeiki, Fatemeh, Bohlooli, Shahab, Dogaheh, Hadi Peeri
Format: Article
Language:English
Subjects:
Adult
DEAD-box RNA Helicases - biosynthesis
DEAD-box RNA Helicases - genetics
DGCR8
Dicer
Disability Evaluation
DNA - biosynthesis
DNA - genetics
Drosha
Female
Gene expression
Humans
Male
MicroRNA machinery
MicroRNAs - biosynthesis
MicroRNAs - genetics
Multiple sclerosis
Multiple Sclerosis - genetics
Multiple Sclerosis, Relapsing-Remitting - genetics
Neurology
Polymerase Chain Reaction
Ribonuclease III - biosynthesis
Ribonuclease III - genetics
RNA-Binding Proteins - biosynthesis
RNA-Binding Proteins - genetics
Up-Regulation
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Summary:Abstract We aimed to evaluate the expression of the major components of microRNA biogenesis machinery including Drosha, Dicer and DiGeorge syndrome critical region gene 8 (DGCR8) in multiple sclerosis (MS) patients. The expression levels of these components in relapsing remitting multiple sclerosis (RRMS) patients were significantly up-regulated in comparison to healthy controls. DGCR8 was up-regulated 4.9 times in RRMS patients versus healthy controls, and Drosha was up-regulated 3.58 times. Additionally, the expression level of Dicer was 2.11 times higher in RRMS patients than the healthy controls. In conclusion, our results suggest that overexpression of Drosha, Dicer and DGCR8 may contribute to the pathogenesis of MS. Further investigation may introduce microRNA biogenesis machinery as MS markers and therapeutic targets.
ISSN:0967-5868
1532-2653
DOI:10.1016/j.jocn.2014.06.106