correlation of Tim-3 and IFN-γ expressions in mice infected with Toxoplasma gondii during gestation

The immunoinhibitory receptor T cell immunoglobulin domain and mucin domain-1 (Tim-1) and Tim-3 participate in the regulation of Th immune response as well as innate immunity. However, there is no report about the expression of Tim genes in Toxoplasma gondii-infected experimental models during pregn...

Full description

Saved in:
Bibliographic Details
Published in:Parasitology research (1987) 2015, Vol.114 (1), p.125-132
Main Authors: Fu, Xiaoyin, Wu, Bin, Huang, Bo, Zheng, Huanqin, Huang, Shiguang, Gan, Yan, Shen, Jilong, Lun, Zhao-Rong, Lu, Fangli
Format: Article
Language:English
Subjects:
animal disease models
Animals
Biomedical and Life Sciences
Biomedicine
Female
gene expression
Gene Expression Regulation - physiology
genes
Health aspects
Hepatitis A Virus Cellular Receptor 2
Host-bacteria relationships
Identification and classification
immune response
Immunoglobulins
Immunology
innate immunity
Interferon
interferon-gamma
Interferon-gamma - genetics
Interferon-gamma - metabolism
interleukin-4
lumber
lymph nodes
Medical Microbiology
messenger RNA
Mice
Microbiology
mucins
Original Paper
Pregnancy
Pregnancy Complications, Parasitic - immunology
Pregnancy Complications, Parasitic - metabolism
quantitative polymerase chain reaction
Real-Time Polymerase Chain Reaction
Receptors, Virus - genetics
Receptors, Virus - metabolism
reverse transcriptase polymerase chain reaction
T cells
Toxoplasma
Toxoplasma gondii
Toxoplasmosis, Animal - metabolism
vagina
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The immunoinhibitory receptor T cell immunoglobulin domain and mucin domain-1 (Tim-1) and Tim-3 participate in the regulation of Th immune response as well as innate immunity. However, there is no report about the expression of Tim genes in Toxoplasma gondii-infected experimental models during pregnancy. In this study, Kunming outbred pregnant mice were infected with RH strain of T. gondii through vagina at days 10 to 16 of gestation, and the mRNA expressions of Tim-1, Tim-3, interleukin (IL)-4, and interferon (IFN)-γ in the placentas, uteri, and draining lumber aortic lymph nodes (LALNs) at day 18 of gestation were analyzed using quantitative real-time PCR (qRT-PCR). Compared with uninfected pregnant controls, significantly increased levels of IFN-γ and Tim-3 were detected in the placentas (P 
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-014-4167-3