Effects of Cigarette Smoke Extract and Nicotine on Regulator of G Protein Signaling-2 Expression in Human Airway Smooth Muscle and Bronchial Epithelial Cells

Conclusions Our data suggest that acute exposure of HASM or HBEC to CSE, at either high or low doses does not significantly alter RGS2 expression, in contrast with chronic low dose exposure in HASM. Since RGS2 regulates airway hyperresponsiveness and controls many important epithelial and smooth mus...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB227-AB227
Main Authors: Tabatabaian, Farnaz, MD, Teng, Michael, PhD, Tran, Kim C, Allen-Gipson, Diane, PhD, Tian, Zhi, PhD, Lockey, Richard F., MD, Xie, Yan, PhD, Tu, Yaping, PhD, Casale, Thomas B., MD, FAAAAI
Format: Article
Language:English
Subjects:
Allergy and Immunology
Asthma
Cigarettes
Nicotine
Proteins
Smooth muscle
Online Access:Get full text
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Summary:Conclusions Our data suggest that acute exposure of HASM or HBEC to CSE, at either high or low doses does not significantly alter RGS2 expression, in contrast with chronic low dose exposure in HASM. Since RGS2 regulates airway hyperresponsiveness and controls many important epithelial and smooth muscle cell functions, further study on the effects of cigarette smoke and/or nicotine on airway RGS2 expression and function are warranted.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1675