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H-PGD Synthase (H-PGDS) Gene Expression Increases in Eosinophils of Aspirin Exacerbated Respiratory Disease (AERD) Patients after Oral Graded Aspirin Challenge
Rationale 10% of adult asthmatics suffer from AERD, characterized by adult onset of moderate to severe asthma and nasal polyps, peripheral and tissue eosinophilia, and a hypersensitivity reaction (bronchospasm, rhinorrhea, and/or conjunctivitis) in response to cyclooxygenase-1 (COX-1) inhibition.
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Published in: | Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB160-AB160 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Rationale 10% of adult asthmatics suffer from AERD, characterized by adult onset of moderate to severe asthma and nasal polyps, peripheral and tissue eosinophilia, and a hypersensitivity reaction (bronchospasm, rhinorrhea, and/or conjunctivitis) in response to cyclooxygenase-1 (COX-1) inhibition. |
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ISSN: | 0091-6749 1097-6825 |
DOI: | 10.1016/j.jaci.2014.12.1462 |