IgE and IgA Produced in B Cells with Mast Cells Are Inhibited By Both Anti-CD40 and Anti-OX40L Abs in Mouse Allergic Asthma

Both blocking Abs (anti-CD40 and anti-OX40L Abs) synergistically reduced IgE, IgA and mediator release, and they additively reduced other responses such as number of mast cells, expression of markers, CD40/CD40L, OX40/OX40L, FceRI or FcaRI, co-localization of BMMCs and B cells or IgE/IgA-producing c...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.AB61-AB61
Main Authors: Ro, Jai Youl, PhD, Hong, Gwan Ui, Kim, Nam Goo, Ahn, Young Min, MD
Format: Article
Language:English
Subjects:
Allergies
Allergy and Immunology
Histamine
Immune system
Online Access:Get full text
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Summary:Both blocking Abs (anti-CD40 and anti-OX40L Abs) synergistically reduced IgE, IgA and mediator release, and they additively reduced other responses such as number of mast cells, expression of markers, CD40/CD40L, OX40/OX40L, FceRI or FcaRI, co-localization of BMMCs and B cells or IgE/IgA-producing cells, compared to those in each Ab treatment or to all responses which are increased in BAL cells or lung tissues of OVA-challenged mice and in B cells and mast cells by co-culture.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2014.12.1132