Synthesis and Antiproliferative and Antimicrobial Activity of Methyl-6-Amino-3-Acyl-4-Aryl-5-Cyano-4H-Pyran-2-Carboxylates and their Derivatives

Antiproliferative and antimicrobial activity of methyl-6-amino-3-acyl-4-aryl-5-cyano-4 H -pyran-2-carboxylates and their analogs that were synthesized from methyl-2,4-dioxobutanoates was studied. Studies of their antiproliferative activity at the USA National Cancer Institute under the program NCI 6...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2014-09, Vol.48 (6), p.379-382
Main Authors: Sheverdov, V. P., Andreev, A. Yu, Nasakin, O. E., Gein, V. L.
Format: Article
Language:English
Subjects:
Coumarins
Medicine
Nitriles
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Summary:Antiproliferative and antimicrobial activity of methyl-6-amino-3-acyl-4-aryl-5-cyano-4 H -pyran-2-carboxylates and their analogs that were synthesized from methyl-2,4-dioxobutanoates was studied. Studies of their antiproliferative activity at the USA National Cancer Institute under the program NCI 60 Cell One-Dose Screen found that methyl-6-amino-5-cyano-4-(furan-2-yl)-3-(3-methoxybenzoyl)-4 H -pyran-2-carboxylate had the highest activity, greater than those of busulfan and cisplatin. Methyl-6-amino-3-acetyl-4-phenyl-5-cyano-4 H -pyran-2-carboxylate had antimicrobial activity that was comparable with that of chloramine.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-014-1114-7