Motor phenotype of LRRK2-associated Parkinson's disease: A tunisian longitudinal study

Mutations in the leucine‐rich repeat kinase 2 gene (LRRK2) were found to be a significant cause of late‐onset autosomal dominant forms of Parkinson's disease (PD). To determine the motor characteristics of LRRK2‐related disease, we conducted a longitudinal study of 58 G2019S LRRK2‐associated PD...

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Bibliographic Details
Published in:Movement disorders 2015-02, Vol.30 (2), p.253-258
Main Authors: Nabli, Fatma, Ben Sassi, Samia, Amouri, Rim, Duda, John E., Farrer, Matthew J., Hentati, Fayçal
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
G2019S mutation
Gait - physiology
Genetic Predisposition to Disease
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Longitudinal Studies
longitudinal study
LRRK2 gene
Male
Middle Aged
Movement disorders
Mutation - genetics
PARK8
Parkinson Disease - genetics
Parkinson's disease
Phenotype
Protein-Serine-Threonine Kinases - genetics
Tunisia
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Summary:Mutations in the leucine‐rich repeat kinase 2 gene (LRRK2) were found to be a significant cause of late‐onset autosomal dominant forms of Parkinson's disease (PD). To determine the motor characteristics of LRRK2‐related disease, we conducted a longitudinal study of 58 G2019S LRRK2‐associated PD patients and compared them with genetically undefined (GU) PD patients. Fifty‐eight patients diagnosed with PD‐related LRRK2 G2019S mutation were included in the study and compared with 54 sporadic PD patients with negative tests for LRRK2 G2019S, PINK1, SNCA, PRKN, and DJ1 mutations. Patients were assessed at baseline and after a follow‐up period of 6 years. The Movement Disorder Society–Unified Parkinson's Disease Rating Scale (MDS‐UPDRS), the Hoehn and Yahr, and the Schwab and England scores were determined. Logistic regression was used to examine associations of G2019S mutation status with motor phenotype and rate of motor decline. The LRRK2‐associated PD patients had a mean age of onset of 56.25 ± 12.05 years and in most cases (58.6%) a postural instability gait difficulty (PIGD) phenotype. The mean annual decline in the MDS‐UDRS III motor score and the Hoehn and Yahr staging was of 1.3% and 2%, respectively. The PIGD phenotype predicted a more rapid progression of motor impairment. The PD motor phenotype and motor scores were similar in the LRRK2‐associated PD group and in the GU PD group, with no significant differences in the progression rate of motor impairment. Motor phenotype seems to be similar in LRRK2‐related PD and idiopathic PD. © 2014 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.26097